Optic neuropathy in sheep associated with overdosage of closantel

Alexandre Secorun Borges; Luiz Claudio Nogueria Mendes; Alexandre Lima De Andrade; Gisele Fabrino Machado; Juliana Regina Peiro

Optic neuropathy in sheep associated with overdosage of closantel

Alexandre Secorun Borges, Luiz Claudio Nogueria Mendes, Alexandre Lima De Andrade, Gisele Fabrino Machado, Juliana Regina Peiro

Research output: Contribution to journal › Article › peer-review

Abstract

This report describes clinical and pathological findings in 2 flocks in Brazil where blindness and deaths in sheep occurred after closantel overdosage. Depression, weakness, and blindness affected 37 animals and 17 died in 2 flocks of 190 animals. Two animals submitted for ophthalmic examination showed no inflammation in the anterior segment of both eyes; posterior segment evaluation by indirect ophthalmoscopy suggested retinal degeneration. One postmortem evaluation local spongy vacuolization was in several regions of the brain and the optical nerves had severe axonal degeneration.

Original language	English
Pages (from-to)	378-380
Number of pages	3
Journal	Veterinary and Human Toxicology
Volume	41
Issue number	6
State	Published - Dec 1999
Externally published	Yes

ASJC Scopus subject areas

Toxicology
General Veterinary
Health, Toxicology and Mutagenesis

Cite this

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title = "Optic neuropathy in sheep associated with overdosage of closantel",

abstract = "This report describes clinical and pathological findings in 2 flocks in Brazil where blindness and deaths in sheep occurred after closantel overdosage. Depression, weakness, and blindness affected 37 animals and 17 died in 2 flocks of 190 animals. Two animals submitted for ophthalmic examination showed no inflammation in the anterior segment of both eyes; posterior segment evaluation by indirect ophthalmoscopy suggested retinal degeneration. One postmortem evaluation local spongy vacuolization was in several regions of the brain and the optical nerves had severe axonal degeneration.",

author = "\{Secorun Borges\}, Alexandre and \{Nogueria Mendes\}, \{Luiz Claudio\} and \{Lima De Andrade\}, Alexandre and Machado, \{Gisele Fabrino\} and Peiro, \{Juliana Regina\}",

year = "1999",

month = dec,

language = "English",

volume = "41",

pages = "378--380",

journal = "Veterinary and Human Toxicology",

issn = "0145-6296",

publisher = "Comparative Toxicology Laboratories",

number = "6",

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T1 - Optic neuropathy in sheep associated with overdosage of closantel

AU - Secorun Borges, Alexandre

AU - Nogueria Mendes, Luiz Claudio

AU - Lima De Andrade, Alexandre

AU - Machado, Gisele Fabrino

AU - Peiro, Juliana Regina

PY - 1999/12

Y1 - 1999/12

N2 - This report describes clinical and pathological findings in 2 flocks in Brazil where blindness and deaths in sheep occurred after closantel overdosage. Depression, weakness, and blindness affected 37 animals and 17 died in 2 flocks of 190 animals. Two animals submitted for ophthalmic examination showed no inflammation in the anterior segment of both eyes; posterior segment evaluation by indirect ophthalmoscopy suggested retinal degeneration. One postmortem evaluation local spongy vacuolization was in several regions of the brain and the optical nerves had severe axonal degeneration.

AB - This report describes clinical and pathological findings in 2 flocks in Brazil where blindness and deaths in sheep occurred after closantel overdosage. Depression, weakness, and blindness affected 37 animals and 17 died in 2 flocks of 190 animals. Two animals submitted for ophthalmic examination showed no inflammation in the anterior segment of both eyes; posterior segment evaluation by indirect ophthalmoscopy suggested retinal degeneration. One postmortem evaluation local spongy vacuolization was in several regions of the brain and the optical nerves had severe axonal degeneration.

UR - https://www.scopus.com/pages/publications/0345440136

M3 - Article

C2 - 10592945

AN - SCOPUS:0345440136

SN - 0145-6296

VL - 41

SP - 378

EP - 380

JO - Veterinary and Human Toxicology

JF - Veterinary and Human Toxicology

IS - 6

ER -

Optic neuropathy in sheep associated with overdosage of closantel

Abstract

ASJC Scopus subject areas

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