Ophthalmic Assessment in Patients With Darier Disease

Helwe Hammad, Eldad Adler, Algit Yeshurun, Lena Abayev, Shiraz Vered, Daniel Briscoe, Michael Ziv, Roni P. Dodiuk-Gad

Research output: Contribution to journalArticlepeer-review


Purpose: To assess the prevalence of ophthalmic findings in patients with Darier disease, an autosomal dominant genetic skin disorder, in an effort to evaluate the need for eye examinations in the management of the disease. Design: Prospective observational case series. Methods: Thirty-six individuals with Darier disease were evaluated by both ocular assessment questionnaire and a comprehensive ophthalmic examination (visual acuity, refraction, external examination, and slit-lamp examination) with emphasis on the eyelids, conjunctiva, and cornea. In addition, questionnaire-based medical interview and skin examination were conducted. Results: According to the medical questionnaire, 39% of patients reported eye problems, 36% dry eye, and 42% eye fatigue after prolonged reading. Ocular examination revealed Darier disease lesions on the eyelids in 55% of the patients, blepharitis in 44%, conjunctival hyperemia in 28%, and short tear film break-up time in 83%. There was no significant relationship between any of these ophthalmic findings and systemic retinoid therapy, sex, or age. Conclusions: The high prevalence of blepharitis and dry eye highlights the importance of ophthalmologic evaluation of patients with Darier disease.

Original languageEnglish
Pages (from-to)139-142
Number of pages4
JournalAmerican Journal of Ophthalmology
StatePublished - Jul 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc.

ASJC Scopus subject areas

  • Ophthalmology


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