Open problems in ageing science: a roadmap for biogerontology

Angelo Talay; Aleksey V. Belikov; Paul Ka Po To; Hamid H. Alfatemi; Uri Alon; Joris Deelen; Collin Y. Ewald; David Gems; Vera Gorbunova; Jan Gruber; Sara Hägg; John Hemming; Steve Horvath; Alaattin Kaya; Caitlin J. Lewis; Andrea B. Maier; Maria B. Marinova; Graham Pawelec; Shahaf Peleg; Suresh Rattan; Morten Scheibye-Knudsen; Tomas Schmauck-Medina; Vardan Saroyan; Andrei Seluanov; Alexandra Stolzing; Emma Teeling; Robert W. Williams; Todd White; Maximilian Unfried; João Pedro de Magalhães

doi:10.1007/s11357-025-01964-4

Open problems in ageing science: a roadmap for biogerontology

Angelo Talay, Aleksey V. Belikov, Paul Ka Po To, Hamid H. Alfatemi, Uri Alon, Joris Deelen, Collin Y. Ewald, David Gems, Vera Gorbunova, Jan Gruber, Sara Hägg, John Hemming, Steve Horvath, Alaattin Kaya, Caitlin J. Lewis, Andrea B. Maier, Maria B. Marinova, Graham Pawelec, Shahaf Peleg, Suresh RattanMorten Scheibye-Knudsen, Tomas Schmauck-Medina, Vardan Saroyan, Andrei Seluanov, Alexandra Stolzing, Emma Teeling, Robert W. Williams, Todd White, Maximilian Unfried, João Pedro de Magalhães

Research output: Contribution to journal › Article › peer-review

Abstract

The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems in ageing and longevity science. These questions were collected through community engagement and further analysed using Natural Language Processing to assess their prevalence in the literature and to identify both well-established and emerging research gaps. The final list is categorised into different topics, including molecular and cellular mechanisms of ageing, comparative biology and the use of model organisms, biomarkers and the development of therapeutic interventions. Both long-standing questions and more recent and specific questions are featured. Our comprehensive compilation is available to the biogerontology community on our website (www.longevityknowledge.app). Overall, this work highlights current key research questions in ageing biology and offers a roadmap for fostering future progress in biogerontology.

Original language	English
Journal	GeroScience
DOIs	https://doi.org/10.1007/s11357-025-01964-4
State	Accepted/In press - 2025
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Author(s) 2025.

Keywords

Ageing and longevity science
Biogerontology
Biology of ageing
Database
Natural language processing

ASJC Scopus subject areas

Aging
Veterinary (miscellaneous)
Complementary and alternative medicine
Geriatrics and Gerontology
Cardiology and Cardiovascular Medicine

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10.1007/s11357-025-01964-4

Cite this

Talay, A., Belikov, A. V., To, P. K. P., Alfatemi, H. H., Alon, U., Deelen, J., Ewald, C. Y., Gems, D., Gorbunova, V., Gruber, J., Hägg, S., Hemming, J., Horvath, S., Kaya, A., Lewis, C. J., Maier, A. B., Marinova, M. B., Pawelec, G., Peleg, S., ... de Magalhães, J. P. (Accepted/In press). Open problems in ageing science: a roadmap for biogerontology. GeroScience. https://doi.org/10.1007/s11357-025-01964-4

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title = "Open problems in ageing science: a roadmap for biogerontology",

abstract = "The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems in ageing and longevity science. These questions were collected through community engagement and further analysed using Natural Language Processing to assess their prevalence in the literature and to identify both well-established and emerging research gaps. The final list is categorised into different topics, including molecular and cellular mechanisms of ageing, comparative biology and the use of model organisms, biomarkers and the development of therapeutic interventions. Both long-standing questions and more recent and specific questions are featured. Our comprehensive compilation is available to the biogerontology community on our website (www.longevityknowledge.app). Overall, this work highlights current key research questions in ageing biology and offers a roadmap for fostering future progress in biogerontology.",

keywords = "Ageing and longevity science, Biogerontology, Biology of ageing, Database, Natural language processing",

author = "Angelo Talay and Belikov, \{Aleksey V.\} and To, \{Paul Ka Po\} and Alfatemi, \{Hamid H.\} and Uri Alon and Joris Deelen and Ewald, \{Collin Y.\} and David Gems and Vera Gorbunova and Jan Gruber and Sara H{\"a}gg and John Hemming and Steve Horvath and Alaattin Kaya and Lewis, \{Caitlin J.\} and Maier, \{Andrea B.\} and Marinova, \{Maria B.\} and Graham Pawelec and Shahaf Peleg and Suresh Rattan and Morten Scheibye-Knudsen and Tomas Schmauck-Medina and Vardan Saroyan and Andrei Seluanov and Alexandra Stolzing and Emma Teeling and Williams, \{Robert W.\} and Todd White and Maximilian Unfried and \{de Magalh{\~a}es\}, \{Jo{\~a}o Pedro\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2025",

doi = "10.1007/s11357-025-01964-4",

language = "English",

journal = "GeroScience",

issn = "2509-2715",

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Talay, A, Belikov, AV, To, PKP, Alfatemi, HH, Alon, U, Deelen, J, Ewald, CY, Gems, D, Gorbunova, V, Gruber, J, Hägg, S, Hemming, J, Horvath, S, Kaya, A, Lewis, CJ, Maier, AB, Marinova, MB, Pawelec, G, Peleg, S, Rattan, S, Scheibye-Knudsen, M, Schmauck-Medina, T, Saroyan, V, Seluanov, A, Stolzing, A, Teeling, E, Williams, RW, White, T, Unfried, M & de Magalhães, JP 2025, 'Open problems in ageing science: a roadmap for biogerontology', GeroScience. https://doi.org/10.1007/s11357-025-01964-4

TY - JOUR

T1 - Open problems in ageing science

T2 - a roadmap for biogerontology

AU - Talay, Angelo

AU - Belikov, Aleksey V.

AU - To, Paul Ka Po

AU - Alfatemi, Hamid H.

AU - Alon, Uri

AU - Deelen, Joris

AU - Ewald, Collin Y.

AU - Gems, David

AU - Gorbunova, Vera

AU - Gruber, Jan

AU - Hägg, Sara

AU - Hemming, John

AU - Horvath, Steve

AU - Kaya, Alaattin

AU - Lewis, Caitlin J.

AU - Maier, Andrea B.

AU - Marinova, Maria B.

AU - Pawelec, Graham

AU - Peleg, Shahaf

AU - Rattan, Suresh

AU - Scheibye-Knudsen, Morten

AU - Schmauck-Medina, Tomas

AU - Saroyan, Vardan

AU - Seluanov, Andrei

AU - Stolzing, Alexandra

AU - Teeling, Emma

AU - Williams, Robert W.

AU - White, Todd

AU - Unfried, Maximilian

AU - de Magalhães, João Pedro

PY - 2025

Y1 - 2025

N2 - The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems in ageing and longevity science. These questions were collected through community engagement and further analysed using Natural Language Processing to assess their prevalence in the literature and to identify both well-established and emerging research gaps. The final list is categorised into different topics, including molecular and cellular mechanisms of ageing, comparative biology and the use of model organisms, biomarkers and the development of therapeutic interventions. Both long-standing questions and more recent and specific questions are featured. Our comprehensive compilation is available to the biogerontology community on our website (www.longevityknowledge.app). Overall, this work highlights current key research questions in ageing biology and offers a roadmap for fostering future progress in biogerontology.

AB - The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems in ageing and longevity science. These questions were collected through community engagement and further analysed using Natural Language Processing to assess their prevalence in the literature and to identify both well-established and emerging research gaps. The final list is categorised into different topics, including molecular and cellular mechanisms of ageing, comparative biology and the use of model organisms, biomarkers and the development of therapeutic interventions. Both long-standing questions and more recent and specific questions are featured. Our comprehensive compilation is available to the biogerontology community on our website (www.longevityknowledge.app). Overall, this work highlights current key research questions in ageing biology and offers a roadmap for fostering future progress in biogerontology.

KW - Ageing and longevity science

KW - Biogerontology

KW - Biology of ageing

KW - Database

KW - Natural language processing

UR - https://www.scopus.com/pages/publications/105021248837

U2 - 10.1007/s11357-025-01964-4

DO - 10.1007/s11357-025-01964-4

M3 - Article

C2 - 41205028

AN - SCOPUS:105021248837

SN - 2509-2715

JO - GeroScience

JF - GeroScience

ER -

Open problems in ageing science: a roadmap for biogerontology

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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