Ontogenetic development of peripheral benzodiazepine binding sites in rat brain, heart and lung

Fuad Fares; Abraham Weizman; David Zlotogorski; Moshe Gavish

doi:10.1016/0006-8993(87)90410-0

Ontogenetic development of peripheral benzodiazepine binding sites in rat brain, heart and lung

Fuad Fares, Abraham Weizman, David Zlotogorski, Moshe Gavish

Research output: Contribution to journal › Article › peer-review

Abstract

In rats, the brain exhibits negligible ontogenetic changes, while a steady marked increase in the density of peripheral benzodiazepine binding sites (PBS) has been demonstrated in the heart and lungs, reaching maximal levels at 31 days after birth. It may be that PBS play a role in the cellular proliferation of these peripheral organs. The present findings are consistent with current evidence of a relationship between these binding sites and mitochondrial function.

Original language	English
Pages (from-to)	381-384
Number of pages	4
Journal	Brain Research
Volume	408
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(87)90410-0
State	Published - 7 Apr 1987
Externally published	Yes

Keywords

Brain
Heart
Lung
Ontogenetic development
Peripheral benzodiazepine binding site
[3H]PK 11195

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0006-8993(87)90410-0

Cite this

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AU - Fares, Fuad

AU - Weizman, Abraham

AU - Zlotogorski, David

AU - Gavish, Moshe

PY - 1987/4/7

Y1 - 1987/4/7

N2 - In rats, the brain exhibits negligible ontogenetic changes, while a steady marked increase in the density of peripheral benzodiazepine binding sites (PBS) has been demonstrated in the heart and lungs, reaching maximal levels at 31 days after birth. It may be that PBS play a role in the cellular proliferation of these peripheral organs. The present findings are consistent with current evidence of a relationship between these binding sites and mitochondrial function.

AB - In rats, the brain exhibits negligible ontogenetic changes, while a steady marked increase in the density of peripheral benzodiazepine binding sites (PBS) has been demonstrated in the heart and lungs, reaching maximal levels at 31 days after birth. It may be that PBS play a role in the cellular proliferation of these peripheral organs. The present findings are consistent with current evidence of a relationship between these binding sites and mitochondrial function.

KW - Brain

KW - Heart

KW - Lung

KW - Ontogenetic development

KW - Peripheral benzodiazepine binding site

KW - [3H]PK 11195

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ER -

Ontogenetic development of peripheral benzodiazepine binding sites in rat brain, heart and lung

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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