Ontogenetic development of peripheral benzodiazepine binding sites in rat brain, heart and lung

Fuad Fares, Abraham Weizman, David Zlotogorski, Moshe Gavish

Research output: Contribution to journalArticlepeer-review

Abstract

In rats, the brain exhibits negligible ontogenetic changes, while a steady marked increase in the density of peripheral benzodiazepine binding sites (PBS) has been demonstrated in the heart and lungs, reaching maximal levels at 31 days after birth. It may be that PBS play a role in the cellular proliferation of these peripheral organs. The present findings are consistent with current evidence of a relationship between these binding sites and mitochondrial function.

Original languageEnglish
Pages (from-to)381-384
Number of pages4
JournalBrain Research
Volume408
Issue number1-2
DOIs
StatePublished - 7 Apr 1987
Externally publishedYes

Keywords

  • Brain
  • Heart
  • Lung
  • Ontogenetic development
  • Peripheral benzodiazepine binding site
  • [3H]PK 11195

ASJC Scopus subject areas

  • Neuroscience (all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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