Olfactory-learning abilities are correlated with the rate by which intrinsic neuronal excitability is modulated in the piriform cortex

Sivan I. Cohen-Matsliah, Kobi Rosenblum, Edi Barkai

Research output: Contribution to journalArticlepeer-review


Long-lasting modulation of intrinsic neuronal excitability in cortical neurons underlies distinct stages of skill learning. However, whether individual differences in learning capabilities are dependent on the rate by which such learning-induced modifications occur has yet to be explored. Here we show that training rats in a simple olfactory-discrimination task results in the same enhanced excitability in piriform cortex neurons as previously shown after training in a much more complex olfactory-discrimination task. Based on their learning capabilities in the simple task, rats could be divided to two groups: fast performers and slow performers. The rate at which rats accomplished the skill to perform the simple task was correlated with the time course at which piriform cortex neurons increased their repetitive spike firing. Twelve hours after learning, neurons from fast performers had reduced spike frequency adaptation as compared with neurons from slow performers and controls. Three days after learning, spike frequency adaptation was reduced in neurons from SP, while neurons from fast performers increased their spike firing adaptation to the level of controls. Accordingly, the post-burst AHP was reduced in neurons from fast performers 12 h after learning and in neurons from slow performers 3 days after learning. Moreover, the differences in learning capabilities between fast performers and slow performers were maintained when examined in a different, complex olfactory-discrimination task. We suggest that the rate at which neuronal excitability is modified during learning may affect the behavioral flexibility of the animal.

Original languageEnglish
Pages (from-to)1339-1348
Number of pages10
JournalEuropean Journal of Neuroscience
Issue number7
StatePublished - Oct 2009


  • AHP
  • Olfactory learning
  • Piriform cortex
  • Pyramidal neurons
  • Rat

ASJC Scopus subject areas

  • General Neuroscience


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