Off-line consolidation of motor sequence learning results in greater integration within a cortico-striatal functional network

Karen Debas, Julie Carrier, Marc Barakat, Guillaume Marrelec, Pierre Bellec, Abdallah Hadj Tahar, Avi Karni, Leslie G. Ungerleider, Habib Benali, Julien Doyon

Research output: Contribution to journalArticlepeer-review

Abstract

The consolidation of motor sequence learning is known to depend on sleep. Work in our laboratory and others have shown that the striatum is associated with this off-line consolidation process. In this study, we aimed to quantify the sleep-dependent dynamic changes occurring at the network level using a measure of functional integration. We directly compared changes in connectivity before and after sleep or the simple passage of daytime. As predicted, the results revealed greater integration within the cortico-striatal network after sleep, but not an equivalent daytime period. Importantly, a similar pattern of results was also observed using a data-driven approach; the increase in integration being specific to a cortico-striatal network, but not to other known functional networks. These findings reveal, for the first time, a new signature of motor sequence consolidation: a greater between-regions interaction within the cortico-striatal system.

Original languageEnglish
Pages (from-to)50-58
Number of pages9
JournalNeuroImage
Volume99
DOIs
StatePublished - 1 Oct 2014

Bibliographical note

Funding Information:
Support for this research was provided by a Canadian Institutes of Health Research ( 86463 ) grant to JD, JC, AHT, AK, HB and LGU, and by a fellowship from the Fonds de recherche du Québec santé to KD (folder number # 20882 ). The authors are grateful to Vo An Nguyen, Estelle Breton and Laurence Girouard for their help in data acquisition.

Keywords

  • Consolidation
  • FMRI
  • Functional connectivity
  • Motor learning
  • Networks
  • Sleep

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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