Abstract
The consolidation of motor sequence learning is known to depend on sleep. Work in our laboratory and others have shown that the striatum is associated with this off-line consolidation process. In this study, we aimed to quantify the sleep-dependent dynamic changes occurring at the network level using a measure of functional integration. We directly compared changes in connectivity before and after sleep or the simple passage of daytime. As predicted, the results revealed greater integration within the cortico-striatal network after sleep, but not an equivalent daytime period. Importantly, a similar pattern of results was also observed using a data-driven approach; the increase in integration being specific to a cortico-striatal network, but not to other known functional networks. These findings reveal, for the first time, a new signature of motor sequence consolidation: a greater between-regions interaction within the cortico-striatal system.
Original language | English |
---|---|
Pages (from-to) | 50-58 |
Number of pages | 9 |
Journal | NeuroImage |
Volume | 99 |
DOIs | |
State | Published - 1 Oct 2014 |
Bibliographical note
Funding Information:Support for this research was provided by a Canadian Institutes of Health Research ( 86463 ) grant to JD, JC, AHT, AK, HB and LGU, and by a fellowship from the Fonds de recherche du Québec santé to KD (folder number # 20882 ). The authors are grateful to Vo An Nguyen, Estelle Breton and Laurence Girouard for their help in data acquisition.
Keywords
- Consolidation
- FMRI
- Functional connectivity
- Motor learning
- Networks
- Sleep
ASJC Scopus subject areas
- Neurology
- Cognitive Neuroscience