OCT as a monitoring tool for assessment of the stage and severity of multiple sclerosis

Yoav Yechezkel Pikkel, Muneer Abu Sneina, Vadim Igal, Yael Sara Pikkel Igal, Adi Nov-Sharabi, Ayelet Armon-Omer, Radi Shahien, Joseph Pikkel

Research output: Contribution to journalArticlepeer-review


AIM: To identify a link between optical coherence tomography (OCT), length of multiple sclerosis (MS) and the expanded disability status scale (EDSS). METHODS: In a prospective double blind study, 29 patients with a diagnosis of MS were compared with 29 healthy patients, matched by age and sex. All participants underwent an OCT study and neurological EDSS test on the same day. RESULTS: The mean EDSS score was 3.2 in the MS group vs 0.03 in the control group, and the duration of MS was 11.7y. The mean retinal nerve fiber layer (RNFL) thickness was significantly thinner in those with MS (P<0.001). Correlation was found between duration of MS and RNFL thinning. EDSS and thinning of RNFL showed a tendency to correlate but without statistical significance. CONCLUSION: RNFL is thinner in MS patients than in the general population. MS duration has a direct statistically significant effect on RNFL thickness. There seems to be a tendency of a relationship between RNFL thinning and EDSS. OCT is suggested as a monitoring and evaluation tool of MS patients.

Original languageEnglish
Pages (from-to)2132-2136
Number of pages5
JournalInternational Eye Science
Issue number12
StatePublished - 8 Dec 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright 2018 by the IJO Press.


  • Expanded disability status scale
  • Multiple sclerosis
  • Ocular coherence tomography
  • Retinal nerve fibrous layer

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'OCT as a monitoring tool for assessment of the stage and severity of multiple sclerosis'. Together they form a unique fingerprint.

Cite this