TY - JOUR
T1 - Occupational exposure to asbestos and man-made vitreous fibres and risk of lung cancer
T2 - A multicentre case-control study in Europe
AU - Carel, Rafael
AU - Olsson, Ann C.
AU - Zaridze, David
AU - Szeszenia-Dabrowska, Neonila
AU - Rudnai, Peter
AU - Lissowska, Jolanta
AU - Fabianova, Eleonora
AU - Cassidy, Adrian
AU - Mates, Dana
AU - Bencko, Vladimir
AU - Foretova, Lenka
AU - Janout, Vladimir
AU - Fevotte, Joelle
AU - Fletcher, Tony
AU - 'T Mannetje, Andrea
AU - Brennan, Paul
AU - Boffetta, Paolo
PY - 2007/8
Y1 - 2007/8
N2 - Objectives: To investigate the contribution of occupational exposure to asbestos and man-made vitreous fibres (MMVF) to lung cancer in high-risk populations in Europe. Methods: A multicentre case-control study was conducted in six Central and Eastern European countries and the UK, during the period 1998-2002. Comprehensive occupational and sociodemographic information was collected from 2205 newly diagnosed male lung cancer cases and 2305 frequency matched controls. Odds ratios (OR) of lung cancer were calculated after adjusting for other relevant occupational exposures and tobacco smoking. Results: The OR for asbestos exposure was 0.92 (95% CI 0.73 to 1.15) in Central and Eastern Europe and 1.85 (95% CI 1.07 to 3.21) in the UK. Similar ORs were found for exposure to amphibole asbestos. The OR for MMVF exposure was 1.23 (95% CI 0.88 to 1.71) with no evidence of heterogeneity by country. No synergistic effect either between asbestos and MMVF or between any of them and smoking was found. Conclusion: In this large community-based study occupational exposure to asbestos and MMVF does not appear to contribute to the lung cancer burden in men in Central and Eastern Europe. In contrast, in the UK the authors found an increased risk of lung cancer following exposure to asbestos. Differences in fibre type and circumstances of exposure may explain these results.
AB - Objectives: To investigate the contribution of occupational exposure to asbestos and man-made vitreous fibres (MMVF) to lung cancer in high-risk populations in Europe. Methods: A multicentre case-control study was conducted in six Central and Eastern European countries and the UK, during the period 1998-2002. Comprehensive occupational and sociodemographic information was collected from 2205 newly diagnosed male lung cancer cases and 2305 frequency matched controls. Odds ratios (OR) of lung cancer were calculated after adjusting for other relevant occupational exposures and tobacco smoking. Results: The OR for asbestos exposure was 0.92 (95% CI 0.73 to 1.15) in Central and Eastern Europe and 1.85 (95% CI 1.07 to 3.21) in the UK. Similar ORs were found for exposure to amphibole asbestos. The OR for MMVF exposure was 1.23 (95% CI 0.88 to 1.71) with no evidence of heterogeneity by country. No synergistic effect either between asbestos and MMVF or between any of them and smoking was found. Conclusion: In this large community-based study occupational exposure to asbestos and MMVF does not appear to contribute to the lung cancer burden in men in Central and Eastern Europe. In contrast, in the UK the authors found an increased risk of lung cancer following exposure to asbestos. Differences in fibre type and circumstances of exposure may explain these results.
UR - http://www.scopus.com/inward/record.url?scp=34547556556&partnerID=8YFLogxK
U2 - 10.1136/oem.2006.027748
DO - 10.1136/oem.2006.027748
M3 - Article
C2 - 17053017
AN - SCOPUS:34547556556
SN - 1351-0711
VL - 64
SP - 502
EP - 508
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
IS - 8
ER -
