Occupational and Environmental Cholangiocarcinoma-Related Toxic Exposures

Tianyu She; Nairuti Shah; Benna Jacob; Nathan Starkman; Julie Lieman; Amandeep Kaur; Neal Shah; Marc Wilkenfeld

doi:10.1159/000541868

Occupational and Environmental Cholangiocarcinoma-Related Toxic Exposures

Tianyu She, Nairuti Shah, Benna Jacob, Nathan Starkman, Julie Lieman, Amandeep Kaur, Neal Shah, Marc Wilkenfeld

Research output: Contribution to journal › Review article › peer-review

Abstract

Cholangiocarcinoma (CCA) is a malignancy that originates from the epithelial cells of the biliary system. Despite advancements in medical diagnostic techniques, CCAs remain a challenge to detect due to their silent clinical progression, making it difficult to diagnose these diseases. There are several well-established risk factors for CCA, including biliary tract infection and inflammation. However, there is also growing evidence that community and occupational exposures play a significant role in the development of bile duct cancers. This review examines the geographical distribution of these risk factors and the importance of surveillance in individuals exposed to these toxins who are more prone to developing CCA.

Original language	English
Pages (from-to)	151-160
Number of pages	10
Journal	GE Portuguese Journal of Gastroenterology
Volume	32
Issue number	3
DOIs	https://doi.org/10.1159/000541868
State	Published - 7 Nov 2024
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2024 The Author(s).

Keywords

Cholangiocarcinoma
Extrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma
Occupational exposures
Toxic exposures

ASJC Scopus subject areas

Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000541868

Cite this

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title = "Occupational and Environmental Cholangiocarcinoma-Related Toxic Exposures",

abstract = "Cholangiocarcinoma (CCA) is a malignancy that originates from the epithelial cells of the biliary system. Despite advancements in medical diagnostic techniques, CCAs remain a challenge to detect due to their silent clinical progression, making it difficult to diagnose these diseases. There are several well-established risk factors for CCA, including biliary tract infection and inflammation. However, there is also growing evidence that community and occupational exposures play a significant role in the development of bile duct cancers. This review examines the geographical distribution of these risk factors and the importance of surveillance in individuals exposed to these toxins who are more prone to developing CCA.",

keywords = "Cholangiocarcinoma, Extrahepatic cholangiocarcinoma, Intrahepatic cholangiocarcinoma, Occupational exposures, Toxic exposures",

author = "Tianyu She and Nairuti Shah and Benna Jacob and Nathan Starkman and Julie Lieman and Amandeep Kaur and Neal Shah and Marc Wilkenfeld",

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doi = "10.1159/000541868",

language = "English",

volume = "32",

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TY - JOUR

T1 - Occupational and Environmental Cholangiocarcinoma-Related Toxic Exposures

AU - She, Tianyu

AU - Shah, Nairuti

AU - Jacob, Benna

AU - Starkman, Nathan

AU - Lieman, Julie

AU - Kaur, Amandeep

AU - Shah, Neal

AU - Wilkenfeld, Marc

PY - 2024/11/7

Y1 - 2024/11/7

N2 - Cholangiocarcinoma (CCA) is a malignancy that originates from the epithelial cells of the biliary system. Despite advancements in medical diagnostic techniques, CCAs remain a challenge to detect due to their silent clinical progression, making it difficult to diagnose these diseases. There are several well-established risk factors for CCA, including biliary tract infection and inflammation. However, there is also growing evidence that community and occupational exposures play a significant role in the development of bile duct cancers. This review examines the geographical distribution of these risk factors and the importance of surveillance in individuals exposed to these toxins who are more prone to developing CCA.

AB - Cholangiocarcinoma (CCA) is a malignancy that originates from the epithelial cells of the biliary system. Despite advancements in medical diagnostic techniques, CCAs remain a challenge to detect due to their silent clinical progression, making it difficult to diagnose these diseases. There are several well-established risk factors for CCA, including biliary tract infection and inflammation. However, there is also growing evidence that community and occupational exposures play a significant role in the development of bile duct cancers. This review examines the geographical distribution of these risk factors and the importance of surveillance in individuals exposed to these toxins who are more prone to developing CCA.

KW - Cholangiocarcinoma

KW - Extrahepatic cholangiocarcinoma

KW - Intrahepatic cholangiocarcinoma

KW - Occupational exposures

KW - Toxic exposures

UR - https://www.scopus.com/pages/publications/85209763619

U2 - 10.1159/000541868

DO - 10.1159/000541868

M3 - Review article

C2 - 40469206

AN - SCOPUS:85209763619

SN - 2341-4545

VL - 32

SP - 151

EP - 160

JO - GE Portuguese Journal of Gastroenterology

JF - GE Portuguese Journal of Gastroenterology

IS - 3

ER -

Occupational and Environmental Cholangiocarcinoma-Related Toxic Exposures

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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