Norepinephrine: Reversal of anorexia in rats with lateral hypothalamic Damage

Barry D. Berger, C. David Wise, Larry Stein

Research output: Contribution to journalArticlepeer-review


Injection of norepinephrine in the lateral ventricles of rats recovering from lateral hypothalamic anorexia caused immediate feeding and, frequently, overeating. Intraventricular administration of the α-noradrenergic blocker, phen tolamine, suppressed feeding in both normal rats and rats that had recovered from lateral hypothalamic lesions. Feeding is reinforced by ascending medial forebrain bundle fibers that form α-noradrenergic synapses in the hypothalamus and forebrain. Damage to these fibers suppresses feeding by reducing noradre nergic transmission and, hence, the rewarding value of food. Recovery of feeding after hypothalamic lesions coincides with the recovery of noradrenergic reward function.

Original languageEnglish
Pages (from-to)281-284
Number of pages4
Issue number3980
StatePublished - 1971
Externally publishedYes

ASJC Scopus subject areas

  • General


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