Norepinephrine: Reversal of anorexia in rats with lateral hypothalamic Damage

Barry D. Berger; C. David Wise; Larry Stein

doi:10.1126/science.172.3980.281

Norepinephrine: Reversal of anorexia in rats with lateral hypothalamic Damage

Barry D. Berger, C. David Wise, Larry Stein

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Abstract

Injection of norepinephrine in the lateral ventricles of rats recovering from lateral hypothalamic anorexia caused immediate feeding and, frequently, overeating. Intraventricular administration of the α-noradrenergic blocker, phen tolamine, suppressed feeding in both normal rats and rats that had recovered from lateral hypothalamic lesions. Feeding is reinforced by ascending medial forebrain bundle fibers that form α-noradrenergic synapses in the hypothalamus and forebrain. Damage to these fibers suppresses feeding by reducing noradre nergic transmission and, hence, the rewarding value of food. Recovery of feeding after hypothalamic lesions coincides with the recovery of noradrenergic reward function.

Original language	English
Pages (from-to)	281-284
Number of pages	4
Journal	Science
Volume	172
Issue number	3980
DOIs	https://doi.org/10.1126/science.172.3980.281
State	Published - 1971
Externally published	Yes

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title = "Norepinephrine: Reversal of anorexia in rats with lateral hypothalamic Damage",

abstract = "Injection of norepinephrine in the lateral ventricles of rats recovering from lateral hypothalamic anorexia caused immediate feeding and, frequently, overeating. Intraventricular administration of the α-noradrenergic blocker, phen tolamine, suppressed feeding in both normal rats and rats that had recovered from lateral hypothalamic lesions. Feeding is reinforced by ascending medial forebrain bundle fibers that form α-noradrenergic synapses in the hypothalamus and forebrain. Damage to these fibers suppresses feeding by reducing noradre nergic transmission and, hence, the rewarding value of food. Recovery of feeding after hypothalamic lesions coincides with the recovery of noradrenergic reward function.",

author = "Berger, {Barry D.} and Wise, {C. David} and Larry Stein",

year = "1971",

doi = "10.1126/science.172.3980.281",

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AB - Injection of norepinephrine in the lateral ventricles of rats recovering from lateral hypothalamic anorexia caused immediate feeding and, frequently, overeating. Intraventricular administration of the α-noradrenergic blocker, phen tolamine, suppressed feeding in both normal rats and rats that had recovered from lateral hypothalamic lesions. Feeding is reinforced by ascending medial forebrain bundle fibers that form α-noradrenergic synapses in the hypothalamus and forebrain. Damage to these fibers suppresses feeding by reducing noradre nergic transmission and, hence, the rewarding value of food. Recovery of feeding after hypothalamic lesions coincides with the recovery of noradrenergic reward function.

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Norepinephrine: Reversal of anorexia in rats with lateral hypothalamic Damage

Abstract

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