Pancreatic cancer has an extremely highly case fatality. Diabetes is a well-established strong risk factor for pancreatic cancer. Compared with a nondiabetic population, we previously reported a 15- and 14-fold greater risk for detecting pancreatic cancer during the first year after diagnosing diabetes in adult women and men, respectively, which dropped during the second year to 5.4-fold and 3.5-fold, respectively, and stabilized around 3-fold for the rest of the 11-year follow-up in our historical cohort. The population attributable risk during the 11-year period was 13.3% and 14.1% in prevalent diabetic women and men, respectively. This means that one out of about every 8 patients diagnosed with pancreatic cancer has been previously diagnosed with diabetes. The globally high prevalence of diabetes and the aggravating implications of a delayed pancreatic cancer diagnosis call for newly-onset diabetes to be considered a potential marker for an underlying pancreatic cancer and addressed accordingly.
Bibliographical noteFunding Information:
The original study was funded by the European Foundation for the
The original study was funded by the European Foundation for the Study of Diabetes (EFSD). We would like to acknowledge Prof Ran Balicer for his collaboration on data acquisition.
Copyright © 2018 John Wiley & Sons, Ltd.
- early detection
- newly diagnosed diabetes
- pancreatic cancer
- population attributable risk PAR
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism