New locus for skin intrinsic fluorescence in type 1 diabetes also associated with blood and skin glycated proteins

Delnaz Roshandel; Ronald Klein; Barbara E.K. Klein; Bruce H.R. Wolffenbuttel; Melanie M. Van Der Klauw; Jana V. Van Vliet-Ostaptchouk; Gil Atzmon; Danny Ben-Avraham; Jill P. Crandall; Nir Barzilai; Shelley B. Bull; Angelo J. Canty; S. Mohsen Hosseini; Linda T. Hiraki; John Maynard; David R. Sell; Vincent M. Monnier; Patricia A. Cleary; Barbara H. Braffett; Andrew D. Paterson

doi:10.2337/db15-1484

New locus for skin intrinsic fluorescence in type 1 diabetes also associated with blood and skin glycated proteins

Delnaz Roshandel
, Ronald Klein
, Barbara E.K. Klein
, Bruce H.R. Wolffenbuttel
, Melanie M. Van Der Klauw
, Jana V. Van Vliet-Ostaptchouk
, Gil Atzmon
, Danny Ben-Avraham
, Jill P. Crandall
, Nir Barzilai
, Shelley B. Bull
, Angelo J. Canty
, S. Mohsen Hosseini
, Linda T. Hiraki
, John Maynard
, David R. Sell
, Vincent M. Monnier
, Patricia A. Cleary
, Barbara H. Braffett
, Andrew D. Paterson

Department of Human Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Skin fluorescence (SF) noninvasively measures advanced glycation end products (AGEs) in the skin and is a risk indicator for diabetes complications. N-acetyltransferase 2 (NAT2) is the only known locus influencing SF. We aimed to identify additional genetic loci influencing SF in type 1 diabetes (T1D) through a meta-analysis of genomewide association studies (N = 1,359) including Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) and Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR). A locus on chromosome 1, rs7533564 (P = 1.9 × 10^-9), was associated with skin intrinsic fluorescence measured by SCOUT DS (excitation 375 nm, emission 435-655 nm), which remained significant after adjustment for time-weighted HbA_1c (P = 1.7 × 10^-8). rs7533564 was associated with mean HbA_1c in meta-analysis (P = 0.0225), mean glycated albumin (P = 0.0029), and glyoxal hydroimidazolones (P = 0.049), an AGE measured in skin biopsy collagen, in DCCT. rs7533564 was not associated with diabetes complications in DCCT/EDIC or with SF in subjects without diabetes (nondiabetic [ND]) (N = 8,721). In conclusion, we identified a new locus associated with SF in T1D subjects that did not show similar effect in ND subjects, suggesting a diabetes-specific effect. This association needs to be investigated in type 2 diabetes.

Original language	English
Pages (from-to)	2060-2071
Number of pages	12
Journal	Diabetes
Volume	65
Issue number	7
DOIs	https://doi.org/10.2337/db15-1484
State	Published - 1 Jul 2016

Bibliographical note

Publisher Copyright:
© 2016 by the American Diabetes Association.

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2337/db15-1484

Cite this

Roshandel, D., Klein, R., Klein, B. E. K., Wolffenbuttel, B. H. R., Van Der Klauw, M. M., Van Vliet-Ostaptchouk, J. V., Atzmon, G., Ben-Avraham, D., Crandall, J. P., Barzilai, N., Bull, S. B., Canty, A. J., Hosseini, S. M., Hiraki, L. T., Maynard, J., Sell, D. R., Monnier, V. M., Cleary, P. A., Braffett, B. H., & Paterson, A. D. (2016). New locus for skin intrinsic fluorescence in type 1 diabetes also associated with blood and skin glycated proteins. Diabetes, 65(7), 2060-2071. https://doi.org/10.2337/db15-1484

@article{383c26ce09d64ab58ac34f67fd41267d,

title = "New locus for skin intrinsic fluorescence in type 1 diabetes also associated with blood and skin glycated proteins",

abstract = "Skin fluorescence (SF) noninvasively measures advanced glycation end products (AGEs) in the skin and is a risk indicator for diabetes complications. N-acetyltransferase 2 (NAT2) is the only known locus influencing SF. We aimed to identify additional genetic loci influencing SF in type 1 diabetes (T1D) through a meta-analysis of genomewide association studies (N = 1,359) including Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) and Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR). A locus on chromosome 1, rs7533564 (P = 1.9 × 10-9), was associated with skin intrinsic fluorescence measured by SCOUT DS (excitation 375 nm, emission 435-655 nm), which remained significant after adjustment for time-weighted HbA1c (P = 1.7 × 10-8). rs7533564 was associated with mean HbA1c in meta-analysis (P = 0.0225), mean glycated albumin (P = 0.0029), and glyoxal hydroimidazolones (P = 0.049), an AGE measured in skin biopsy collagen, in DCCT. rs7533564 was not associated with diabetes complications in DCCT/EDIC or with SF in subjects without diabetes (nondiabetic [ND]) (N = 8,721). In conclusion, we identified a new locus associated with SF in T1D subjects that did not show similar effect in ND subjects, suggesting a diabetes-specific effect. This association needs to be investigated in type 2 diabetes.",

author = "Delnaz Roshandel and Ronald Klein and Klein, \{Barbara E.K.\} and Wolffenbuttel, \{Bruce H.R.\} and \{Van Der Klauw\}, \{Melanie M.\} and \{Van Vliet-Ostaptchouk\}, \{Jana V.\} and Gil Atzmon and Danny Ben-Avraham and Crandall, \{Jill P.\} and Nir Barzilai and Bull, \{Shelley B.\} and Canty, \{Angelo J.\} and Hosseini, \{S. Mohsen\} and Hiraki, \{Linda T.\} and John Maynard and Sell, \{David R.\} and Monnier, \{Vincent M.\} and Cleary, \{Patricia A.\} and Braffett, \{Barbara H.\} and Paterson, \{Andrew D.\}",

note = "Publisher Copyright: {\textcopyright} 2016 by the American Diabetes Association.",

year = "2016",

month = jul,

day = "1",

doi = "10.2337/db15-1484",

language = "English",

volume = "65",

pages = "2060--2071",

journal = "Diabetes",

issn = "0012-1797",

publisher = "American Diabetes Association Inc.",

number = "7",

}

Roshandel, D, Klein, R, Klein, BEK, Wolffenbuttel, BHR, Van Der Klauw, MM, Van Vliet-Ostaptchouk, JV, Atzmon, G, Ben-Avraham, D, Crandall, JP, Barzilai, N, Bull, SB, Canty, AJ, Hosseini, SM, Hiraki, LT, Maynard, J, Sell, DR, Monnier, VM, Cleary, PA, Braffett, BH & Paterson, AD 2016, 'New locus for skin intrinsic fluorescence in type 1 diabetes also associated with blood and skin glycated proteins', Diabetes, vol. 65, no. 7, pp. 2060-2071. https://doi.org/10.2337/db15-1484

TY - JOUR

T1 - New locus for skin intrinsic fluorescence in type 1 diabetes also associated with blood and skin glycated proteins

AU - Roshandel, Delnaz

AU - Klein, Ronald

AU - Klein, Barbara E.K.

AU - Wolffenbuttel, Bruce H.R.

AU - Van Der Klauw, Melanie M.

AU - Van Vliet-Ostaptchouk, Jana V.

AU - Atzmon, Gil

AU - Ben-Avraham, Danny

AU - Crandall, Jill P.

AU - Barzilai, Nir

AU - Bull, Shelley B.

AU - Canty, Angelo J.

AU - Hosseini, S. Mohsen

AU - Hiraki, Linda T.

AU - Maynard, John

AU - Sell, David R.

AU - Monnier, Vincent M.

AU - Cleary, Patricia A.

AU - Braffett, Barbara H.

AU - Paterson, Andrew D.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Skin fluorescence (SF) noninvasively measures advanced glycation end products (AGEs) in the skin and is a risk indicator for diabetes complications. N-acetyltransferase 2 (NAT2) is the only known locus influencing SF. We aimed to identify additional genetic loci influencing SF in type 1 diabetes (T1D) through a meta-analysis of genomewide association studies (N = 1,359) including Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) and Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR). A locus on chromosome 1, rs7533564 (P = 1.9 × 10-9), was associated with skin intrinsic fluorescence measured by SCOUT DS (excitation 375 nm, emission 435-655 nm), which remained significant after adjustment for time-weighted HbA1c (P = 1.7 × 10-8). rs7533564 was associated with mean HbA1c in meta-analysis (P = 0.0225), mean glycated albumin (P = 0.0029), and glyoxal hydroimidazolones (P = 0.049), an AGE measured in skin biopsy collagen, in DCCT. rs7533564 was not associated with diabetes complications in DCCT/EDIC or with SF in subjects without diabetes (nondiabetic [ND]) (N = 8,721). In conclusion, we identified a new locus associated with SF in T1D subjects that did not show similar effect in ND subjects, suggesting a diabetes-specific effect. This association needs to be investigated in type 2 diabetes.

AB - Skin fluorescence (SF) noninvasively measures advanced glycation end products (AGEs) in the skin and is a risk indicator for diabetes complications. N-acetyltransferase 2 (NAT2) is the only known locus influencing SF. We aimed to identify additional genetic loci influencing SF in type 1 diabetes (T1D) through a meta-analysis of genomewide association studies (N = 1,359) including Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) and Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR). A locus on chromosome 1, rs7533564 (P = 1.9 × 10-9), was associated with skin intrinsic fluorescence measured by SCOUT DS (excitation 375 nm, emission 435-655 nm), which remained significant after adjustment for time-weighted HbA1c (P = 1.7 × 10-8). rs7533564 was associated with mean HbA1c in meta-analysis (P = 0.0225), mean glycated albumin (P = 0.0029), and glyoxal hydroimidazolones (P = 0.049), an AGE measured in skin biopsy collagen, in DCCT. rs7533564 was not associated with diabetes complications in DCCT/EDIC or with SF in subjects without diabetes (nondiabetic [ND]) (N = 8,721). In conclusion, we identified a new locus associated with SF in T1D subjects that did not show similar effect in ND subjects, suggesting a diabetes-specific effect. This association needs to be investigated in type 2 diabetes.

UR - https://www.scopus.com/pages/publications/84975883796

U2 - 10.2337/db15-1484

DO - 10.2337/db15-1484

M3 - Article

C2 - 27207532

AN - SCOPUS:84975883796

SN - 0012-1797

VL - 65

SP - 2060

EP - 2071

JO - Diabetes

JF - Diabetes

IS - 7

ER -

New locus for skin intrinsic fluorescence in type 1 diabetes also associated with blood and skin glycated proteins

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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