We report here that phased runs of adenines and thymines are very frequent in the neighborhood of 3′ of the coding regions of Escherichia coli and Bacillus subtilis. These findings suggest that the DNA curvature could affect transcription termination either directly, through contacts with RNA polymerase, or indirectly, via contacts with some regulatory proteins.
Bibliographical noteFunding Information:
We thank all members of the Genome D iversity Center for fruitful discussions and critical comments on the paper. A.B. is grateful to Professors T. Ratiu and J.H. Maddocks from the Bernoulli Institute at the Swiss Federal Institute of Technology for the kind invitation to visit Centre Bernoulli for two months. S.H. and A.B. were partially supported by the FIRST Foundation of the Israel Academy of Science and Humanities.
ASJC Scopus subject areas
- Molecular Biology
- Structural Biology