NEURONAL-ASTROCYTIC REGULATION OF GLUTAMATE HOMEOSTASIS: RELEVANCE TO COGNITIVE DYSFUNCTION IN SCHIZOPHRENIA

Inna Gaisler-Salomon, Sharon S. Lander, Darpan Chakraborty, Kfir Asraf, Hazem Safory, Herman Wolosker, Hanoch Kaphzan

Research output: Contribution to journalConference articlepeer-review

Abstract

Glutamatergic abnormalities are commonly observed in schizophrenia (SZ) and are hypothesized to play an important role in cognitive dysfunction. While the contribution of postsynaptic glutamate receptors to SZ psychopathology has been extensively examined, less is known about the role played by enzymes involved in glutamate metabolism and homeostasis. We examined mice with a brain-wide deficit in the glutamate metabolizing enzyme glutamate dehydrogenase (GDH), encoded by Glud1, which leads to glutamate excess due to reduced glutamate metabolism in astrocytes.
Original languageEnglish
Pages (from-to)S124
Number of pages1
JournalSchizophrenia Bulletin
Volume45
Issue numberSuppl 2
DOIs
StatePublished - Apr 2019

Bibliographical note

Congress of the Schizophrenia-International-Research-Society (SRIS), Orlando, FL, APR 10-14, 2019

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