TY - JOUR
T1 - NEURONAL-ASTROCYTIC REGULATION OF GLUTAMATE HOMEOSTASIS
T2 - RELEVANCE TO COGNITIVE DYSFUNCTION IN SCHIZOPHRENIA
AU - Gaisler-Salomon, Inna
AU - Lander, Sharon S.
AU - Chakraborty, Darpan
AU - Asraf, Kfir
AU - Safory, Hazem
AU - Wolosker, Herman
AU - Kaphzan, Hanoch
N1 - Congress of the Schizophrenia-International-Research-Society (SRIS), Orlando, FL, APR 10-14, 2019
PY - 2019/4
Y1 - 2019/4
N2 - Glutamatergic abnormalities are commonly observed in schizophrenia (SZ) and are hypothesized to play an important role in cognitive dysfunction. While the contribution of postsynaptic glutamate receptors to SZ psychopathology has been extensively examined, less is known about the role played by enzymes involved in glutamate metabolism and homeostasis. We examined mice with a brain-wide deficit in the glutamate metabolizing enzyme glutamate dehydrogenase (GDH), encoded by Glud1, which leads to glutamate excess due to reduced glutamate metabolism in astrocytes.
AB - Glutamatergic abnormalities are commonly observed in schizophrenia (SZ) and are hypothesized to play an important role in cognitive dysfunction. While the contribution of postsynaptic glutamate receptors to SZ psychopathology has been extensively examined, less is known about the role played by enzymes involved in glutamate metabolism and homeostasis. We examined mice with a brain-wide deficit in the glutamate metabolizing enzyme glutamate dehydrogenase (GDH), encoded by Glud1, which leads to glutamate excess due to reduced glutamate metabolism in astrocytes.
U2 - 10.1093/schbul/sbz022.087
DO - 10.1093/schbul/sbz022.087
M3 - Conference article
SN - 0586-7614
VL - 45
SP - S124
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
IS - Suppl 2
ER -