Neurobiological consequences of juvenile stress: A GABAergic perspective on risk and resilience

Anne Albrecht, Iris Müller, Ziv Ardi, Gürsel Çalışkan, David Gruber, Sebastian Ivens, Menahem Segal, Joachim Behr, Uwe Heinemann, Oliver Stork, Gal Richter-Levin

Research output: Contribution to journalReview articlepeer-review


ALBRECHT, A., MÜLLER, I., ARDI, Z., ÇALIŞKAN, G., GRUBER, D., IVENS, S., SEGAL, M., BEHR, J., HEINEMANN, U., STORK, O., and RICHTER-LEVIN, G. Neurobiological consequences of juvenile stress: A GABAergic perspective on risk and resilience. NEUROSCI BIOBEHAV REV XXX-XXX, 2016. – Childhood adversity is among the most potent risk factors for developing mood and anxiety disorders later in life. Therefore, understanding how stress during childhood shapes and rewires the brain may optimize preventive and therapeutic strategies for these disorders. To this end, animal models of stress exposure in rodents during their post-weaning and pre-pubertal life phase have been developed. Such ‘juvenile stress’ has a long-lasting impact on mood and anxiety-like behavior and on stress coping in adulthood, accompanied by alterations of the GABAergic system within core regions for the stress processing such as the amygdala, prefrontal cortex and hippocampus. While many regionally diverse molecular and electrophysiological changes are observed, not all of them correlate with juvenile stress-induced behavioral disturbances. It rather seems that certain juvenile stress-induced alterations reflect the system's attempts to maintain homeostasis and thus promote stress resilience. Analysis tools such as individual behavioral profiling may allow the association of behavioral and neurobiological alterations more clearly and the dissection of alterations related to the pathology from those related to resilience.

Original languageEnglish
Pages (from-to)21-43
Number of pages23
JournalNeuroscience and Biobehavioral Reviews
StatePublished - 1 Mar 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd


  • Anxiety
  • Behavioral profiling
  • Corticosterone
  • Dentate gyrus
  • Dorsal and ventral hippocampus
  • GABAergic system
  • HPA axis
  • Juvenile stress
  • Posttraumatic stress disorder
  • Resilience

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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