Network integration of the adrenergic system in cardiac hypertrophy

Liza Barki-Harrington; Cinzia Perrino; Howard A. Rockman

doi:10.1016/j.cardiores.2004.03.011

Network integration of the adrenergic system in cardiac hypertrophy

Liza Barki-Harrington, Cinzia Perrino, Howard A. Rockman

Research output: Contribution to journal › Review article › peer-review

Abstract

Adrenergic receptors play a pivotal role in regulating cardiac function in response to a constantly changing environment. Altered α and β adrenergic receptor signaling in vivo is associated with cardiac hypertrophy and failure. This review focuses on the different roles of adrenergic receptors in regulating cardiac function under normal and pathological conditions. Understanding the signaling mechanisms of these receptors in the context of the heart is likely to provide a better therapeutic approach towards treatment of heart failure.

Original language	English
Pages (from-to)	391-402
Number of pages	12
Journal	Cardiovascular Research
Volume	63
Issue number	3
DOIs	https://doi.org/10.1016/j.cardiores.2004.03.011
State	Published - 15 Aug 2004
Externally published	Yes

Keywords

Adrenergic receptors
Cardiac hypertrophy
Heart failure

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cardiores.2004.03.011

Cite this

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title = "Network integration of the adrenergic system in cardiac hypertrophy",

abstract = "Adrenergic receptors play a pivotal role in regulating cardiac function in response to a constantly changing environment. Altered α and β adrenergic receptor signaling in vivo is associated with cardiac hypertrophy and failure. This review focuses on the different roles of adrenergic receptors in regulating cardiac function under normal and pathological conditions. Understanding the signaling mechanisms of these receptors in the context of the heart is likely to provide a better therapeutic approach towards treatment of heart failure.",

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AU - Perrino, Cinzia

AU - Rockman, Howard A.

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N2 - Adrenergic receptors play a pivotal role in regulating cardiac function in response to a constantly changing environment. Altered α and β adrenergic receptor signaling in vivo is associated with cardiac hypertrophy and failure. This review focuses on the different roles of adrenergic receptors in regulating cardiac function under normal and pathological conditions. Understanding the signaling mechanisms of these receptors in the context of the heart is likely to provide a better therapeutic approach towards treatment of heart failure.

AB - Adrenergic receptors play a pivotal role in regulating cardiac function in response to a constantly changing environment. Altered α and β adrenergic receptor signaling in vivo is associated with cardiac hypertrophy and failure. This review focuses on the different roles of adrenergic receptors in regulating cardiac function under normal and pathological conditions. Understanding the signaling mechanisms of these receptors in the context of the heart is likely to provide a better therapeutic approach towards treatment of heart failure.

KW - Adrenergic receptors

KW - Cardiac hypertrophy

KW - Heart failure

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M3 - Review article

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ER -

Network integration of the adrenergic system in cardiac hypertrophy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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