Network integration of the adrenergic system in cardiac hypertrophy

Liza Barki-Harrington, Cinzia Perrino, Howard A. Rockman

Research output: Contribution to journalReview articlepeer-review

Abstract

Adrenergic receptors play a pivotal role in regulating cardiac function in response to a constantly changing environment. Altered α and β adrenergic receptor signaling in vivo is associated with cardiac hypertrophy and failure. This review focuses on the different roles of adrenergic receptors in regulating cardiac function under normal and pathological conditions. Understanding the signaling mechanisms of these receptors in the context of the heart is likely to provide a better therapeutic approach towards treatment of heart failure.

Original languageEnglish
Pages (from-to)391-402
Number of pages12
JournalCardiovascular Research
Volume63
Issue number3
DOIs
StatePublished - 15 Aug 2004
Externally publishedYes

Keywords

  • Adrenergic receptors
  • Cardiac hypertrophy
  • Heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Physiology

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