Nerve mediated responses to drugs and electrical stimulation in aganglionic muscle segments in Hirschsprung's disease

M. Hanani, O. Z. Lernau, O. Zamir, S. Nissan

Research output: Contribution to journalArticlepeer-review

Abstract

The activity of isolated muscle strips from normal and aganglionic human large bowel was studied in vitro. The intrinsic nerves were stimulated electrically and by nicotinic agonists. The ganglionic preparations displayed a strong inhibitory response due to the release of both norepinephrine and a noncholinergic, nonadrenergic inhibitory neurotransmitter. In the aganglionic strips (obtained from patients with Hirschsprung's disease), nerve activation tended to evoke contraction, apparently due to enhancement in the release of acetylcholine. At the same time, the release of norepinephrine appeared to be less than normal. A particularly interesting finding in the aganglionic muscle strips was the presence of a substantial inhibitory response due to the release of a noncholinergic, nonadrenergic substance. These results provide further evidence for the importance of the innervation of the aganglionic segment in Hirschsprung's disease.

Original languageEnglish
Pages (from-to)848-851
Number of pages4
JournalJournal of Pediatric Surgery
Volume21
Issue number10
DOIs
StatePublished - Oct 1986
Externally publishedYes

Keywords

  • aganglionic megacolon
  • Hirschsprung's disease

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Fingerprint

Dive into the research topics of 'Nerve mediated responses to drugs and electrical stimulation in aganglionic muscle segments in Hirschsprung's disease'. Together they form a unique fingerprint.

Cite this