Abstract
A single dose of NGF (4 μg), injected in the lateral ventricle immediately after the placement of lateral hypothalamic lesions, facilitated the course of recovery from the lateral hypothalamic anorexic syndrome. In the second and third weeks after lesion placement, a group of twelve NGF treated rats ate more food (P<.05), regained body weight more rapidly (P<.05), and fed more vigorously in response to intraventricular administration of norepinephrine (P<.01) than did a group of thirteen controls injected with Ringer Locke solution. After full recovery (2 months after surgery), rats treated with nerve growth factor were more resistant (P<.025) to the reinstatement of the anorexic syndrome produced by a second intraventricular injection of 6 hydroxydopamine (25 μg) than were untreated controls. Nerve growth factor may facilitate behavioral recovery after damage to noradrenergic systems both by promoting the development of supersensitivity to norepinephrine and by stimulating the growth of regenerating noradrenergic neurons.
| Original language | English |
|---|---|
| Pages (from-to) | 925 |
| Number of pages | 1 |
| Journal | Federation Proceedings |
| Volume | 32 |
| Issue number | 3 I |
| State | Published - 1973 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine (all)