Nerve growth factor (NGF): enchanced recovery of feeding after lateral hypothalamic damage

L. Stein, B. D. Berger, C. D. Wise

Research output: Contribution to journalArticlepeer-review


A single dose of NGF (4 μg), injected in the lateral ventricle immediately after the placement of lateral hypothalamic lesions, facilitated the course of recovery from the lateral hypothalamic anorexic syndrome. In the second and third weeks after lesion placement, a group of twelve NGF treated rats ate more food (P<.05), regained body weight more rapidly (P<.05), and fed more vigorously in response to intraventricular administration of norepinephrine (P<.01) than did a group of thirteen controls injected with Ringer Locke solution. After full recovery (2 months after surgery), rats treated with nerve growth factor were more resistant (P<.025) to the reinstatement of the anorexic syndrome produced by a second intraventricular injection of 6 hydroxydopamine (25 μg) than were untreated controls. Nerve growth factor may facilitate behavioral recovery after damage to noradrenergic systems both by promoting the development of supersensitivity to norepinephrine and by stimulating the growth of regenerating noradrenergic neurons.

Original languageEnglish
Pages (from-to)925
Number of pages1
JournalFederation Proceedings
Issue number3 I
StatePublished - 1973
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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