Negative impact of 'old-to-old' donations on success of cadaveric renal transplants

Inbal Weiss-Salz; Micha Mandel; Noya Galai; Geoffrey Boner; Eytan Mor; Richard Nakache; Elisheva Simchen; Tamar Ashkenazi; Ahmed Eid; Jonathan Halevi; Aaron Hoffman; Ron Loewenthal; Solly Mizrahi; Ruth Rahamimov; Anat Rotem; Moshe Shabtai

doi:10.1111/j.1399-0012.2005.00353.x

Negative impact of 'old-to-old' donations on success of cadaveric renal transplants

Inbal Weiss-Salz, Micha Mandel, Noya Galai, Geoffrey Boner, Eytan Mor, Richard Nakache, Elisheva Simchen, Tamar Ashkenazi, Ahmed Eid, Jonathan Halevi, Aaron Hoffman, Ron Loewenthal, Solly Mizrahi, Ruth Rahamimov, Anat Rotem, Moshe Shabtai

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of 'old-to-old' cadaveric renal transplants on operative complications and graft survival was assessed in all 325 patients undergoing solitary cadaveric renal transplantations in Israel during a 3-yr period. Preoperative information and hospital course data were abstracted from the charts. Results were analyzed using Kaplan-Meyer survival curves, univariate and multivariate Cox models. Overall, 62 (19.1%) grafts failed within a year. Failure rate was 46.2% for 'old-to-old' transplants compared with 15.5% for all other donor/recipient age combinations (p < 0.0001). 'Old-to-old' transplants remained independently associated with graft failure in a multivariate Cox model after controlling the effect of other risk factors. 'Old-to-old' transplants were also associated with increased operative complications relative to other age combinations. The decision to use 'old-to-old' transplants, even when donors are scarce, is problematic and should be reconsidered.

Original language	English
Pages (from-to)	372-376
Number of pages	5
Journal	Clinical Transplantation
Volume	19
Issue number	3
DOIs	https://doi.org/10.1111/j.1399-0012.2005.00353.x
State	Published - Jun 2005
Externally published	Yes

Keywords

'Old-to-old' transplants
Cadaveric kidney transplant
Graft failure
Operative complications

ASJC Scopus subject areas

Transplantation

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10.1111/j.1399-0012.2005.00353.x

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Weiss-Salz, I., Mandel, M., Galai, N., Boner, G., Mor, E., Nakache, R., Simchen, E., Ashkenazi, T., Eid, A., Halevi, J., Hoffman, A., Loewenthal, R., Mizrahi, S., Rahamimov, R., Rotem, A., & Shabtai, M. (2005). Negative impact of 'old-to-old' donations on success of cadaveric renal transplants. Clinical Transplantation, 19(3), 372-376. https://doi.org/10.1111/j.1399-0012.2005.00353.x

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title = "Negative impact of 'old-to-old' donations on success of cadaveric renal transplants",

abstract = "The effect of 'old-to-old' cadaveric renal transplants on operative complications and graft survival was assessed in all 325 patients undergoing solitary cadaveric renal transplantations in Israel during a 3-yr period. Preoperative information and hospital course data were abstracted from the charts. Results were analyzed using Kaplan-Meyer survival curves, univariate and multivariate Cox models. Overall, 62 (19.1%) grafts failed within a year. Failure rate was 46.2% for 'old-to-old' transplants compared with 15.5% for all other donor/recipient age combinations (p < 0.0001). 'Old-to-old' transplants remained independently associated with graft failure in a multivariate Cox model after controlling the effect of other risk factors. 'Old-to-old' transplants were also associated with increased operative complications relative to other age combinations. The decision to use 'old-to-old' transplants, even when donors are scarce, is problematic and should be reconsidered.",

keywords = "'Old-to-old' transplants, Cadaveric kidney transplant, Graft failure, Operative complications",

author = "Inbal Weiss-Salz and Micha Mandel and Noya Galai and Geoffrey Boner and Eytan Mor and Richard Nakache and Elisheva Simchen and Tamar Ashkenazi and Ahmed Eid and Jonathan Halevi and Aaron Hoffman and Ron Loewenthal and Solly Mizrahi and Ruth Rahamimov and Anat Rotem and Moshe Shabtai",

year = "2005",

month = jun,

doi = "10.1111/j.1399-0012.2005.00353.x",

language = "English",

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Weiss-Salz, I, Mandel, M, Galai, N, Boner, G, Mor, E, Nakache, R, Simchen, E, Ashkenazi, T, Eid, A, Halevi, J, Hoffman, A, Loewenthal, R, Mizrahi, S, Rahamimov, R, Rotem, A & Shabtai, M 2005, 'Negative impact of 'old-to-old' donations on success of cadaveric renal transplants', Clinical Transplantation, vol. 19, no. 3, pp. 372-376. https://doi.org/10.1111/j.1399-0012.2005.00353.x

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T1 - Negative impact of 'old-to-old' donations on success of cadaveric renal transplants

AU - Weiss-Salz, Inbal

AU - Mandel, Micha

AU - Galai, Noya

AU - Boner, Geoffrey

AU - Mor, Eytan

AU - Nakache, Richard

AU - Simchen, Elisheva

AU - Ashkenazi, Tamar

AU - Eid, Ahmed

AU - Halevi, Jonathan

AU - Hoffman, Aaron

AU - Loewenthal, Ron

AU - Mizrahi, Solly

AU - Rahamimov, Ruth

AU - Rotem, Anat

AU - Shabtai, Moshe

PY - 2005/6

Y1 - 2005/6

N2 - The effect of 'old-to-old' cadaveric renal transplants on operative complications and graft survival was assessed in all 325 patients undergoing solitary cadaveric renal transplantations in Israel during a 3-yr period. Preoperative information and hospital course data were abstracted from the charts. Results were analyzed using Kaplan-Meyer survival curves, univariate and multivariate Cox models. Overall, 62 (19.1%) grafts failed within a year. Failure rate was 46.2% for 'old-to-old' transplants compared with 15.5% for all other donor/recipient age combinations (p < 0.0001). 'Old-to-old' transplants remained independently associated with graft failure in a multivariate Cox model after controlling the effect of other risk factors. 'Old-to-old' transplants were also associated with increased operative complications relative to other age combinations. The decision to use 'old-to-old' transplants, even when donors are scarce, is problematic and should be reconsidered.

AB - The effect of 'old-to-old' cadaveric renal transplants on operative complications and graft survival was assessed in all 325 patients undergoing solitary cadaveric renal transplantations in Israel during a 3-yr period. Preoperative information and hospital course data were abstracted from the charts. Results were analyzed using Kaplan-Meyer survival curves, univariate and multivariate Cox models. Overall, 62 (19.1%) grafts failed within a year. Failure rate was 46.2% for 'old-to-old' transplants compared with 15.5% for all other donor/recipient age combinations (p < 0.0001). 'Old-to-old' transplants remained independently associated with graft failure in a multivariate Cox model after controlling the effect of other risk factors. 'Old-to-old' transplants were also associated with increased operative complications relative to other age combinations. The decision to use 'old-to-old' transplants, even when donors are scarce, is problematic and should be reconsidered.

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KW - Cadaveric kidney transplant

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Negative impact of 'old-to-old' donations on success of cadaveric renal transplants

Abstract

Keywords

ASJC Scopus subject areas

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