Natural selection favors a newly derived timeless allele in Drosophila melanogaster

Eran Tauber; Mauro Zordan; Federica Sandrelli; Mirko Pegoraro; Nicolò Osterwalder; Carlo Breda; Andrea Daga; Alessandro Selmin; Karen Monger; Clara Benna; Ezio Rosato; Charalambos P. Kyriacou; Rodolfo Costa

doi:10.1126/science.1138412

Natural selection favors a newly derived timeless allele in Drosophila melanogaster

Eran Tauber, Mauro Zordan, Federica Sandrelli, Mirko Pegoraro, Nicolò Osterwalder, Carlo Breda, Andrea Daga, Alessandro Selmin, Karen Monger, Clara Benna, Ezio Rosato, Charalambos P. Kyriacou, Rodolfo Costa

Research output: Contribution to journal › Article › peer-review

Abstract

Circadian and other natural clock-like endogenous rhythms may have evolved to anticipate regular temporal changes in the environment. We report that a mutation in the circadian clock gene timeless in Drosophila melanogaster has arisen and spread by natural selection relatively recently in Europe. We found that, when introduced into different genetic backgrounds, natural and artificial alleles of the timeless gene affect the incidence of diapause in response to changes in light and temperature. The natural mutant allele alters an important life history trait that may enhance the fly's adaptation to seasonal conditions.

Original language	English
Pages (from-to)	1895-1898
Number of pages	4
Journal	Science
Volume	316
Issue number	5833
DOIs	https://doi.org/10.1126/science.1138412
State	Published - 29 Jun 2007
Externally published	Yes

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title = "Natural selection favors a newly derived timeless allele in Drosophila melanogaster",

abstract = "Circadian and other natural clock-like endogenous rhythms may have evolved to anticipate regular temporal changes in the environment. We report that a mutation in the circadian clock gene timeless in Drosophila melanogaster has arisen and spread by natural selection relatively recently in Europe. We found that, when introduced into different genetic backgrounds, natural and artificial alleles of the timeless gene affect the incidence of diapause in response to changes in light and temperature. The natural mutant allele alters an important life history trait that may enhance the fly's adaptation to seasonal conditions.",

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T1 - Natural selection favors a newly derived timeless allele in Drosophila melanogaster

AU - Tauber, Eran

AU - Zordan, Mauro

AU - Sandrelli, Federica

AU - Pegoraro, Mirko

AU - Osterwalder, Nicolò

AU - Breda, Carlo

AU - Daga, Andrea

AU - Selmin, Alessandro

AU - Monger, Karen

AU - Benna, Clara

AU - Rosato, Ezio

AU - Kyriacou, Charalambos P.

AU - Costa, Rodolfo

PY - 2007/6/29

Y1 - 2007/6/29

N2 - Circadian and other natural clock-like endogenous rhythms may have evolved to anticipate regular temporal changes in the environment. We report that a mutation in the circadian clock gene timeless in Drosophila melanogaster has arisen and spread by natural selection relatively recently in Europe. We found that, when introduced into different genetic backgrounds, natural and artificial alleles of the timeless gene affect the incidence of diapause in response to changes in light and temperature. The natural mutant allele alters an important life history trait that may enhance the fly's adaptation to seasonal conditions.

AB - Circadian and other natural clock-like endogenous rhythms may have evolved to anticipate regular temporal changes in the environment. We report that a mutation in the circadian clock gene timeless in Drosophila melanogaster has arisen and spread by natural selection relatively recently in Europe. We found that, when introduced into different genetic backgrounds, natural and artificial alleles of the timeless gene affect the incidence of diapause in response to changes in light and temperature. The natural mutant allele alters an important life history trait that may enhance the fly's adaptation to seasonal conditions.

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VL - 316

SP - 1895

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JO - Science

JF - Science

IS - 5833

ER -

Natural selection favors a newly derived timeless allele in Drosophila melanogaster

Abstract

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