Natural products as mediators of disease

Neha Garg; Tal Luzzatto-Knaan; Alexey V. Melnik; Andrés Mauricio Caraballo-Rodríguez; Dimitrios J. Floros; Daniel Petras; Rachel Gregor; Pieter C. Dorrestein; Vanessa V. Phelan

doi:10.1039/c6np00063k

Natural products as mediators of disease

Neha Garg
, Tal Luzzatto-Knaan
, Alexey V. Melnik
, Andrés Mauricio Caraballo-Rodríguez
, Dimitrios J. Floros
, Daniel Petras
, Rachel Gregor
, Pieter C. Dorrestein
, Vanessa V. Phelan

Research output: Contribution to journal › Review article › peer-review

Abstract

Covering: up to 2016 Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.

Original language	English
Pages (from-to)	194-219
Number of pages	26
Journal	Natural Product Reports
Volume	34
Issue number	2
DOIs	https://doi.org/10.1039/c6np00063k
State	Published - Feb 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 The Royal Society of Chemistry.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1039/c6np00063k

Cite this

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title = "Natural products as mediators of disease",

abstract = "Covering: up to 2016 Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.",

author = "Neha Garg and Tal Luzzatto-Knaan and Melnik, \{Alexey V.\} and Caraballo-Rodr{\'i}guez, \{Andr{\'e}s Mauricio\} and Floros, \{Dimitrios J.\} and Daniel Petras and Rachel Gregor and Dorrestein, \{Pieter C.\} and Phelan, \{Vanessa V.\}",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

month = feb,

doi = "10.1039/c6np00063k",

language = "English",

volume = "34",

pages = "194--219",

journal = "Natural Product Reports",

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TY - JOUR

T1 - Natural products as mediators of disease

AU - Garg, Neha

AU - Luzzatto-Knaan, Tal

AU - Melnik, Alexey V.

AU - Caraballo-Rodríguez, Andrés Mauricio

AU - Floros, Dimitrios J.

AU - Petras, Daniel

AU - Gregor, Rachel

AU - Dorrestein, Pieter C.

AU - Phelan, Vanessa V.

PY - 2017/2

Y1 - 2017/2

N2 - Covering: up to 2016 Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.

AB - Covering: up to 2016 Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.

UR - https://www.scopus.com/pages/publications/85012074236

U2 - 10.1039/c6np00063k

DO - 10.1039/c6np00063k

M3 - Review article

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AN - SCOPUS:85012074236

SN - 0265-0568

VL - 34

SP - 194

EP - 219

JO - Natural Product Reports

JF - Natural Product Reports

IS - 2

ER -

Natural products as mediators of disease

Abstract

Bibliographical note

UN SDGs

ASJC Scopus subject areas

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