Natural products as mediators of disease

Neha Garg; Tal Luzzatto-Knaan; Alexey V. Melnik; Andrés Mauricio Caraballo-Rodríguez; Dimitrios J. Floros; Daniel Petras; Rachel Gregor; Pieter C. Dorrestein; Vanessa V. Phelan

doi:10.1039/c6np00063k

Natural products as mediators of disease

Neha Garg, Tal Luzzatto-Knaan, Alexey V. Melnik, Andrés Mauricio Caraballo-Rodríguez, Dimitrios J. Floros, Daniel Petras, Rachel Gregor, Pieter C. Dorrestein, Vanessa V. Phelan

Research output: Contribution to journal › Review article › peer-review

Abstract

Covering: up to 2016 Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.

Original language	English
Pages (from-to)	194-219
Number of pages	26
Journal	Natural Product Reports
Volume	34
Issue number	2
DOIs	https://doi.org/10.1039/c6np00063k
State	Published - Feb 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 The Royal Society of Chemistry.

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c6np00063k

Cite this

@article{32f8e1a2cf514201a55a7b5d4c434615,

title = "Natural products as mediators of disease",

abstract = "Covering: up to 2016 Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.",

author = "Neha Garg and Tal Luzzatto-Knaan and Melnik, {Alexey V.} and Caraballo-Rodr{\'i}guez, {Andr{\'e}s Mauricio} and Floros, {Dimitrios J.} and Daniel Petras and Rachel Gregor and Dorrestein, {Pieter C.} and Phelan, {Vanessa V.}",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

month = feb,

doi = "10.1039/c6np00063k",

language = "English",

volume = "34",

pages = "194--219",

journal = "Natural Product Reports",

issn = "0265-0568",

publisher = "Royal Society of Chemistry",

number = "2",

}

TY - JOUR

T1 - Natural products as mediators of disease

AU - Garg, Neha

AU - Luzzatto-Knaan, Tal

AU - Melnik, Alexey V.

AU - Caraballo-Rodríguez, Andrés Mauricio

AU - Floros, Dimitrios J.

AU - Petras, Daniel

AU - Gregor, Rachel

AU - Dorrestein, Pieter C.

AU - Phelan, Vanessa V.

PY - 2017/2

Y1 - 2017/2

N2 - Covering: up to 2016 Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.

AB - Covering: up to 2016 Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.

UR - http://www.scopus.com/inward/record.url?scp=85012074236&partnerID=8YFLogxK

U2 - 10.1039/c6np00063k

DO - 10.1039/c6np00063k

M3 - Review article

C2 - 27874907

AN - SCOPUS:85012074236

SN - 0265-0568

VL - 34

SP - 194

EP - 219

JO - Natural Product Reports

JF - Natural Product Reports

IS - 2

ER -

Natural products as mediators of disease

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this