Natural products as mediators of disease

Neha Garg; Tal Luzzatto-Knaan; Alexey V. Melnik; Andrés Mauricio Caraballo-Rodríguez; Dimitrios J. Floros; Daniel Petras; Rachel Gregor; Pieter C. Dorrestein; Vanessa V. Phelan

doi:10.1039/c6np00063k

Natural products as mediators of disease

Neha Garg, Tal Luzzatto-Knaan, Alexey V. Melnik, Andrés Mauricio Caraballo-Rodríguez, Dimitrios J. Floros, Daniel Petras, Rachel Gregor, Pieter C. Dorrestein, Vanessa V. Phelan

Research output: Contribution to journal › Review article › peer-review

Abstract

Covering: up to 2016 Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.

Original language	English
Pages (from-to)	194-219
Number of pages	26
Journal	Natural Product Reports
Volume	34
Issue number	2
DOIs	https://doi.org/10.1039/c6np00063k
State	Published - Feb 2017
Externally published	Yes

Bibliographical note

Funding Information:
This work was partially supported by the National Institutes of Health (NIH) Grants 5P41GM103484 (PCD), AI095125 (PCD), GM097509 (PCD), GM094802 (PCD), GM107550 (PCD), S10R029121 (PCD), K01 GM103809 (VVP), the European Union 7th Framework Programme grant 305259 (PCD) and the L.S. Skaggs Professorship (VVP). TLK is supported by the United States - Israel Binational Agricultural Research and Development Fund Vaadia-BARD No. FI-494-13. AMCR is supported by São Paulo Research Foundation (FAPESP) grant #2014/01651-8, 2012/21803-1. DF is supported by NIH Training Grant T32EB009380

Publisher Copyright:
© 2017 The Royal Society of Chemistry.

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c6np00063k

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title = "Natural products as mediators of disease",

abstract = "Covering: up to 2016 Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.",

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note = "Funding Information: This work was partially supported by the National Institutes of Health (NIH) Grants 5P41GM103484 (PCD), AI095125 (PCD), GM097509 (PCD), GM094802 (PCD), GM107550 (PCD), S10R029121 (PCD), K01 GM103809 (VVP), the European Union 7th Framework Programme grant 305259 (PCD) and the L.S. Skaggs Professorship (VVP). TLK is supported by the United States - Israel Binational Agricultural Research and Development Fund Vaadia-BARD No. FI-494-13. AMCR is supported by S{\~a}o Paulo Research Foundation (FAPESP) grant #2014/01651-8, 2012/21803-1. DF is supported by NIH Training Grant T32EB009380 Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

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AU - Petras, Daniel

AU - Gregor, Rachel

AU - Dorrestein, Pieter C.

AU - Phelan, Vanessa V.

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Natural products as mediators of disease

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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