Covering: up to 2016 Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.
Bibliographical noteFunding Information:
This work was partially supported by the National Institutes of Health (NIH) Grants 5P41GM103484 (PCD), AI095125 (PCD), GM097509 (PCD), GM094802 (PCD), GM107550 (PCD), S10R029121 (PCD), K01 GM103809 (VVP), the European Union 7th Framework Programme grant 305259 (PCD) and the L.S. Skaggs Professorship (VVP). TLK is supported by the United States - Israel Binational Agricultural Research and Development Fund Vaadia-BARD No. FI-494-13. AMCR is supported by São Paulo Research Foundation (FAPESP) grant #2014/01651-8, 2012/21803-1. DF is supported by NIH Training Grant T32EB009380
© 2017 The Royal Society of Chemistry.
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry