Multi-interval mapping of correlated trait complexes

A. B. Korol, Y. I. Ronin, E. Nevo, P. M. Hayes

Research output: Contribution to journalArticlepeer-review

Abstract

Employing Monte Carlo simulations, we demonstrate the advantages of multitrait analysis in detection of linked QTL effects within the framework of mixture models. In spite of an increased number of parameters to be estimated, compared to the single-trait formulation, the proposed method allows for an improvement of detection power and estimation precision of linked QTLs in both adjacent or nonadjacent intervals, with coupling and repulsion effects. The results obtained are illustrated by examples based on data of the North American Barley Genome Mapping Project.

Original languageEnglish
Pages (from-to)273-284
Number of pages12
JournalHeredity
Volume80
Issue number3
DOIs
StatePublished - Mar 1998

Bibliographical note

Funding Information:
We acknowledge with thanks the comments and suggestions of two anonymous referees. The work was supported by the Israeli Ministry of Absorption and the Ancell-Teicher Research foundation for Genetics and Molecular Evolution.

Keywords

  • Correlation
  • Linked QTLs
  • LOD-score
  • Maximum likelihood
  • Multiple traits

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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