Molecular mechanisms of long-term potentiation in the insular cortex in vivo.

M. W. Jones, P. J. French, T. V. Bliss, K. Rosenblum

Research output: Contribution to journalArticlepeer-review


We have investigated molecular mechanisms of synaptic plasticity in the pathway between two forebrain structures important for taste learning, the basolateral amygdala (BLA) and the insular cortex. We report here that in vivo long-term potentiation (LTP) induced by BLA stimulation requires functional NMDA receptors and is modulated by muscarinic acetylcholine receptors. In addition, LTP results in the activation of cortical extracellular regulated kinase 1/2 (ERK1/2) and is blocked by inhibitors of ERK1/2 activation. Previous findings demonstrated the involvement of the same molecular mechanisms in the same cortical area during novel taste learning. The results demonstrate that both synaptic and behavioral plasticity share common molecular mechanisms in the insular cortex.

Original languageEnglish
Pages (from-to)RC36
JournalJournal of Neuroscience
Issue number21
StatePublished - 1 Nov 1999
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Molecular mechanisms of long-term potentiation in the insular cortex in vivo.'. Together they form a unique fingerprint.

Cite this