Molecular genetics of the fruit-fly circadian clock

Ezio Rosato, Eran Tauber, Charalambos P. Kyriacou

Research output: Contribution to journalReview articlepeer-review


The circadian clock percolates through every aspect of behaviour and physiology, and has wide implications for human and animal health. The molecular basis of the Drosophila circadian clock provides a model system that has remarkable similarities to that of mammals. The various cardinal clock molecules in the fly are outlined, and compared to those of their actual and 'functional' homologues in the mammal. We also focus on the evolutionary tinkering of these clock genes and compare and contrast the neuronal basis for behavioural rhythms between the two phyla.

Original languageEnglish
Pages (from-to)729-738
Number of pages10
JournalEuropean Journal of Human Genetics
Issue number6
StatePublished - Jun 2006
Externally publishedYes

Bibliographical note

Funding Information:
We thank the BBSRC, NERC and Wellcome Trust for supporting our research, and the Royal Society for a Wolfson Research Merit Award to CPK. We also thank three anonymous referees who put up with, and treated with considerable sympathy, a very rough first draft that was written by one of us (CPK) from memory, during a brief stay in an Italian hospital.


  • Circadian clock
  • Drosophila
  • Molecular genetics

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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