Modulation of social investigation by anterior hypothalamic nucleus rhythmic neural activity

Renad Jabarin; Wael Dagash; Shai Netser; Shelly Singh; Blesson K. Paul; Edi Barkai; Shlomo Wagner

doi:10.1016/j.isci.2022.105921

Modulation of social investigation by anterior hypothalamic nucleus rhythmic neural activity

Renad Jabarin, Wael Dagash, Shai Netser, Shelly Singh, Blesson K. Paul, Edi Barkai, Shlomo Wagner

Research output: Contribution to journal › Article › peer-review

Abstract

Social interactions involve both approach and avoidance toward specific individuals. Currently, the brain regions subserving these behaviors are not fully recognized. The anterior hypothalamic nucleus (AHN) is a poorly defined brain area, and recent studies have yielded contradicting conclusions regarding its behavioral role. Here we explored the role of AHN neuronal activity in regulating approach and avoidance actions during social interactions. Using electrophysiological recordings from behaving mice, we revealed that theta rhythmicity in the AHN is enhanced during affiliative interactions, but decreases during aversive ones. Moreover, the spiking activity of AHN neurons increased during the investigation of social stimuli, as compared to objects, and was modulated by theta rhythmicity. Finally, AHN optogenetic stimulation during social interactions augmented the approach toward stimuli associated with the stimulation. These results suggest the role for AHN neural activity in regulating approach behavior during social interactions, and for theta rhythmicity in mediating the valence of social stimuli.

Original language	English
Article number	105921
Journal	iScience
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.isci.2022.105921
State	Published - 17 Feb 2023

Bibliographical note

Funding Information:
We thank Boris Shklyar, Head of Bioimaging Unit, and Alex Bizer, the experimental systems engineer of the Faculty of Natural Sciences of the University of Haifa, for their help. We also thank Dr. Yair Shemesh from the Weizmann Institute, Rehovot, Israel, for the critical reading of the manuscript draft. This study was supported by the ISF-NSFC joint research program (grant No. 3459/20 to SW), the Israel Science Foundation (grant No. 1361/17 to SW), the Ministry of Science, Technology and Space of Israel (Grant No. 3-12068 to SW) and the United States-Israel Binational Science Foundation (grant No. 2019186 to SW). Conceptualization (SN, SW), methodology (SN), software (SN), validation (SN, SW), formal analysis (RJ, SN, SS, WD), investigation (BKP, RJ, SN, SS, WD), resources (EB), writing – original draft (RJ, SN, SW), writing – review & editing (EB, SN, SW), visualization (RJ, SN), supervision (SW), project administration (SN), and funding acquisition (SW). The authors declare no competing interests. We support inclusive, diverse, and equitable conduct of research.

Funding Information:
We thank Boris Shklyar, Head of Bioimaging Unit, and Alex Bizer, the experimental systems engineer of the Faculty of Natural Sciences of the University of Haifa, for their help. We also thank Dr. Yair Shemesh from the Weizmann Institute, Rehovot, Israel, for the critical reading of the manuscript draft. This study was supported by the ISF- NSFC joint research program (grant No. 3459/20 to SW), the Israel Science Foundation (grant No. 1361/17 to SW), the Ministry of Science, Technology and Space of Israel (Grant No. 3-12068 to SW) and the United States-Israel Binational Science Foundation (grant No. 2019186 to SW).

Publisher Copyright:
© 2022 The Authors

Keywords

Behavioral neuroscience
Biological sciences
Neuroscience
Systems neuroscience

ASJC Scopus subject areas

General

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10.1016/j.isci.2022.105921

Cite this

@article{5e5d22834b26414bb1ec6b5d858d198f,

title = "Modulation of social investigation by anterior hypothalamic nucleus rhythmic neural activity",

abstract = "Social interactions involve both approach and avoidance toward specific individuals. Currently, the brain regions subserving these behaviors are not fully recognized. The anterior hypothalamic nucleus (AHN) is a poorly defined brain area, and recent studies have yielded contradicting conclusions regarding its behavioral role. Here we explored the role of AHN neuronal activity in regulating approach and avoidance actions during social interactions. Using electrophysiological recordings from behaving mice, we revealed that theta rhythmicity in the AHN is enhanced during affiliative interactions, but decreases during aversive ones. Moreover, the spiking activity of AHN neurons increased during the investigation of social stimuli, as compared to objects, and was modulated by theta rhythmicity. Finally, AHN optogenetic stimulation during social interactions augmented the approach toward stimuli associated with the stimulation. These results suggest the role for AHN neural activity in regulating approach behavior during social interactions, and for theta rhythmicity in mediating the valence of social stimuli.",

keywords = "Behavioral neuroscience, Biological sciences, Neuroscience, Systems neuroscience",

author = "Renad Jabarin and Wael Dagash and Shai Netser and Shelly Singh and Paul, {Blesson K.} and Edi Barkai and Shlomo Wagner",

note = "Funding Information: We thank Boris Shklyar, Head of Bioimaging Unit, and Alex Bizer, the experimental systems engineer of the Faculty of Natural Sciences of the University of Haifa, for their help. We also thank Dr. Yair Shemesh from the Weizmann Institute, Rehovot, Israel, for the critical reading of the manuscript draft. This study was supported by the ISF-NSFC joint research program (grant No. 3459/20 to SW), the Israel Science Foundation (grant No. 1361/17 to SW), the Ministry of Science, Technology and Space of Israel (Grant No. 3-12068 to SW) and the United States-Israel Binational Science Foundation (grant No. 2019186 to SW). Conceptualization (SN, SW), methodology (SN), software (SN), validation (SN, SW), formal analysis (RJ, SN, SS, WD), investigation (BKP, RJ, SN, SS, WD), resources (EB), writing – original draft (RJ, SN, SW), writing – review & editing (EB, SN, SW), visualization (RJ, SN), supervision (SW), project administration (SN), and funding acquisition (SW). The authors declare no competing interests. We support inclusive, diverse, and equitable conduct of research. Funding Information: We thank Boris Shklyar, Head of Bioimaging Unit, and Alex Bizer, the experimental systems engineer of the Faculty of Natural Sciences of the University of Haifa, for their help. We also thank Dr. Yair Shemesh from the Weizmann Institute, Rehovot, Israel, for the critical reading of the manuscript draft. This study was supported by the ISF- NSFC joint research program (grant No. 3459/20 to SW), the Israel Science Foundation (grant No. 1361/17 to SW), the Ministry of Science, Technology and Space of Israel (Grant No. 3-12068 to SW) and the United States-Israel Binational Science Foundation (grant No. 2019186 to SW). Publisher Copyright: {\textcopyright} 2022 The Authors",

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AU - Jabarin, Renad

AU - Dagash, Wael

AU - Netser, Shai

AU - Singh, Shelly

AU - Paul, Blesson K.

AU - Barkai, Edi

AU - Wagner, Shlomo

N1 - Funding Information: We thank Boris Shklyar, Head of Bioimaging Unit, and Alex Bizer, the experimental systems engineer of the Faculty of Natural Sciences of the University of Haifa, for their help. We also thank Dr. Yair Shemesh from the Weizmann Institute, Rehovot, Israel, for the critical reading of the manuscript draft. This study was supported by the ISF-NSFC joint research program (grant No. 3459/20 to SW), the Israel Science Foundation (grant No. 1361/17 to SW), the Ministry of Science, Technology and Space of Israel (Grant No. 3-12068 to SW) and the United States-Israel Binational Science Foundation (grant No. 2019186 to SW). Conceptualization (SN, SW), methodology (SN), software (SN), validation (SN, SW), formal analysis (RJ, SN, SS, WD), investigation (BKP, RJ, SN, SS, WD), resources (EB), writing – original draft (RJ, SN, SW), writing – review & editing (EB, SN, SW), visualization (RJ, SN), supervision (SW), project administration (SN), and funding acquisition (SW). The authors declare no competing interests. We support inclusive, diverse, and equitable conduct of research. Funding Information: We thank Boris Shklyar, Head of Bioimaging Unit, and Alex Bizer, the experimental systems engineer of the Faculty of Natural Sciences of the University of Haifa, for their help. We also thank Dr. Yair Shemesh from the Weizmann Institute, Rehovot, Israel, for the critical reading of the manuscript draft. This study was supported by the ISF- NSFC joint research program (grant No. 3459/20 to SW), the Israel Science Foundation (grant No. 1361/17 to SW), the Ministry of Science, Technology and Space of Israel (Grant No. 3-12068 to SW) and the United States-Israel Binational Science Foundation (grant No. 2019186 to SW). Publisher Copyright: © 2022 The Authors

PY - 2023/2/17

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N2 - Social interactions involve both approach and avoidance toward specific individuals. Currently, the brain regions subserving these behaviors are not fully recognized. The anterior hypothalamic nucleus (AHN) is a poorly defined brain area, and recent studies have yielded contradicting conclusions regarding its behavioral role. Here we explored the role of AHN neuronal activity in regulating approach and avoidance actions during social interactions. Using electrophysiological recordings from behaving mice, we revealed that theta rhythmicity in the AHN is enhanced during affiliative interactions, but decreases during aversive ones. Moreover, the spiking activity of AHN neurons increased during the investigation of social stimuli, as compared to objects, and was modulated by theta rhythmicity. Finally, AHN optogenetic stimulation during social interactions augmented the approach toward stimuli associated with the stimulation. These results suggest the role for AHN neural activity in regulating approach behavior during social interactions, and for theta rhythmicity in mediating the valence of social stimuli.

AB - Social interactions involve both approach and avoidance toward specific individuals. Currently, the brain regions subserving these behaviors are not fully recognized. The anterior hypothalamic nucleus (AHN) is a poorly defined brain area, and recent studies have yielded contradicting conclusions regarding its behavioral role. Here we explored the role of AHN neuronal activity in regulating approach and avoidance actions during social interactions. Using electrophysiological recordings from behaving mice, we revealed that theta rhythmicity in the AHN is enhanced during affiliative interactions, but decreases during aversive ones. Moreover, the spiking activity of AHN neurons increased during the investigation of social stimuli, as compared to objects, and was modulated by theta rhythmicity. Finally, AHN optogenetic stimulation during social interactions augmented the approach toward stimuli associated with the stimulation. These results suggest the role for AHN neural activity in regulating approach behavior during social interactions, and for theta rhythmicity in mediating the valence of social stimuli.

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KW - Biological sciences

KW - Neuroscience

KW - Systems neuroscience

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DO - 10.1016/j.isci.2022.105921

M3 - Article

AN - SCOPUS:85146270988

SN - 2589-0042

VL - 26

JO - iScience

JF - iScience

IS - 2

M1 - 105921

ER -

Modulation of social investigation by anterior hypothalamic nucleus rhythmic neural activity

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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