Modulation of organotin-induced apoptosis by the water pollutant methyl mercury in a human lymphoblastoid tumor cell line and a marine sponge

R Batel; N Bihari; B Rinkevich; J Dapper; H Schäcke; HC Schröder; WEG Müller

doi:10.3354/meps093245

Modulation of organotin-induced apoptosis by the water pollutant methyl mercury in a human lymphoblastoid tumor cell line and a marine sponge

R Batel, N Bihari, B Rinkevich, J Dapper, H Schäcke, HC Schröder, WEG Müller

Research output: Contribution to journal › Article › peer-review

Abstract

poptosis IS a special form of cell death in which the cells act~velyparticipate in the process of dying. We found that the water pollutants tnbutylt~n(> 1 P M ) and methyl mercury (MeHg; at concentrations of > 3 FM) induce apoptosls In human T-lymphoblastoid CEM cells and in tlssue of the marlne sponge Geodia cydonium At concentrations of >5 yM. MeHg causes alkaline-labile sites in
DNA of CEM cells. At the lower dose of 0.3 FM, MeHg abolishes the tr~butyltln-inducedapoptosis in both CEM cells and sponge tissue. Incubation of sponge t ~ s s u ew ~ t h3 yM of tnbutyltin Induces not only apoptosis but also a n increased expression of heat shock protein-70.

Original language	English
Pages (from-to)	245-251
Number of pages	7
Journal	Marine Ecology - Progress Series
Volume	93
DOIs	https://doi.org/10.3354/meps093245
State	Published - 1993
Externally published	Yes

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title = "Modulation of organotin-induced apoptosis by the water pollutant methyl mercury in a human lymphoblastoid tumor cell line and a marine sponge",

abstract = "poptosis IS a special form of cell death in which the cells act\textasciitilde{}velyparticipate in the process of dying. We found that the water pollutants tnbutylt\textasciitilde{}n(> 1 P M ) and methyl mercury (MeHg; at concentrations of > 3 FM) induce apoptosls In human T-lymphoblastoid CEM cells and in tlssue of the marlne sponge Geodia cydonium At concentrations of >5 yM. MeHg causes alkaline-labile sites in DNA of CEM cells. At the lower dose of 0.3 FM, MeHg abolishes the tr\textasciitilde{}butyltln-inducedapoptosis in both CEM cells and sponge tissue. Incubation of sponge t \textasciitilde{} s s u ew \textasciitilde{} t h3 yM of tnbutyltin Induces not only apoptosis but also a n increased expression of heat shock protein-70.",

author = "R Batel and N Bihari and B Rinkevich and J Dapper and H Sch{\"a}cke and HC Schr{\"o}der and WEG M{\"u}ller",

year = "1993",

doi = "10.3354/meps093245",

language = "English",

volume = "93",

pages = "245--251",

journal = "Marine Ecology - Progress Series",

issn = "0171-8630",

publisher = "Inter-Research",

}

TY - JOUR

T1 - Modulation of organotin-induced apoptosis by the water pollutant methyl mercury in a human lymphoblastoid tumor cell line and a marine sponge

AU - Batel, R

AU - Bihari, N

AU - Rinkevich, B

AU - Dapper, J

AU - Schäcke, H

AU - Schröder, HC

AU - Müller, WEG

PY - 1993

Y1 - 1993

N2 - poptosis IS a special form of cell death in which the cells act~velyparticipate in the process of dying. We found that the water pollutants tnbutylt~n(> 1 P M ) and methyl mercury (MeHg; at concentrations of > 3 FM) induce apoptosls In human T-lymphoblastoid CEM cells and in tlssue of the marlne sponge Geodia cydonium At concentrations of >5 yM. MeHg causes alkaline-labile sites in DNA of CEM cells. At the lower dose of 0.3 FM, MeHg abolishes the tr~butyltln-inducedapoptosis in both CEM cells and sponge tissue. Incubation of sponge t ~ s s u ew ~ t h3 yM of tnbutyltin Induces not only apoptosis but also a n increased expression of heat shock protein-70.

AB - poptosis IS a special form of cell death in which the cells act~velyparticipate in the process of dying. We found that the water pollutants tnbutylt~n(> 1 P M ) and methyl mercury (MeHg; at concentrations of > 3 FM) induce apoptosls In human T-lymphoblastoid CEM cells and in tlssue of the marlne sponge Geodia cydonium At concentrations of >5 yM. MeHg causes alkaline-labile sites in DNA of CEM cells. At the lower dose of 0.3 FM, MeHg abolishes the tr~butyltln-inducedapoptosis in both CEM cells and sponge tissue. Incubation of sponge t ~ s s u ew ~ t h3 yM of tnbutyltin Induces not only apoptosis but also a n increased expression of heat shock protein-70.

U2 - 10.3354/meps093245

DO - 10.3354/meps093245

M3 - Article

SN - 0171-8630

VL - 93

SP - 245

EP - 251

JO - Marine Ecology - Progress Series

JF - Marine Ecology - Progress Series

ER -

Modulation of organotin-induced apoptosis by the water pollutant methyl mercury in a human lymphoblastoid tumor cell line and a marine sponge

Abstract

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