Modeling pulmonary and CNS O2 toxicity and estimation of parameters for humans

R. Arieli, A. Yalovand, A. Goldenshluger

Research output: Contribution to journalArticlepeer-review


The power expression for cumulative oxygen toxicity and the exponential recovery were successfully applied to various features of oxygen toxicity. From the basic equation, we derived expressions for a protocol in which PO2 changes with time. The parameters of the power equation were solved by using nonlinear regression for the reduction in vital capacity (ΔVC) in humans: %ΔVC = 0.0082 × t2(PO2/101.3)4.57, where t is the time in hours and PO2 is expressed in kPa. The recovery of lung volume is ΔVCt = ΔVCe × e-(-0.42 + 0.00379PO2)t, where ΔVCt is the value at time t of the recovery, ΔVCe is the value at the end of the hyperoxic exposure, and PO2 is the prerecovery oxygen pressure. Data from different experiments on central nervous system (CNS) oxygen toxicity in humans in the hyperbaric chamber (n = 661) were analyzed along with data from actual closed-circuit oxygen diving (n = 2,039) by using a maximum likelihood method. The parameters of the model were solved for the combined data, yielding the power equation for active diving: K = t2 (PO2/101.3)6.8, where t is in minutes. It is suggested that the risk of CNS oxygen toxicity in diving can be derived from the calculated parameter of the normal distribution: Z = [In(t) - 9.63 +3.38 × n(PO2/101.3)]/2.02. The recovery time constant for CNS oxygen toxicity was calculated from the value obtained for the rat, taking into account the effect of body mass, and yielded the recovery equation: Kt = Ke - e-0.079t, where Kt and Ke are the values of K at time t of the recovery process and at the end of the hyperbaric oxygen exposure, respectively, and t is in minutes.

Original languageEnglish
Pages (from-to)248-256
Number of pages9
JournalJournal of Applied Physiology
Issue number1
StatePublished - 2002


  • Central nervous system oxygen toxicity
  • Hyperbaric oxygen
  • Pulmonary oxygen toxicity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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