Modeling and optimization of genetic screens via RNA interference and FACS

Research output: Contribution to journalArticlepeer-review


We study mathematically a method for discovering which gene is related to a cell characteristic (phenotype) of interest. The method is based on RNA interference - a molecular process for gene deactivation - and on coupling the phenotype with cell fluorescence. A small number of candidate genes are thus isolated, and then tested individually. We model probabilistically this process, prove a limit theorem for its outcome, and derive operational guidelines for maximizing the probability of successful gene discovery.

Original languageEnglish
Pages (from-to)131-145
Number of pages15
JournalProbability in the Engineering and Informational Sciences
Issue number1
StatePublished - 29 Sep 2014

Bibliographical note

Publisher Copyright:
Copyright © 2014 Cambridge University Press.

ASJC Scopus subject areas

  • Statistics and Probability
  • Statistics, Probability and Uncertainty
  • Management Science and Operations Research
  • Industrial and Manufacturing Engineering


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