MiRNA and tropism of human parvovirus B19

Olga Berillo; Vladimir Khailenko; Anatoly Ivashchenko; Lior Perlmuter-Shoshany; Alexander Bolshoy

doi:10.1016/j.compbiolchem.2012.06.002

MiRNA and tropism of human parvovirus B19

Olga Berillo, Vladimir Khailenko, Anatoly Ivashchenko, Lior Perlmuter-Shoshany, Alexander Bolshoy

Department of Evolutionary and Environmental Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2. These proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mRNAs were synthesized. Our interpretation of these results is an inhibition of translation in nonpermissive cells by human miRNAs. We bring support to our hypothesis and propose detailed experimental procedure to test it.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Computational Biology and Chemistry
Volume	40
DOIs	https://doi.org/10.1016/j.compbiolchem.2012.06.002
State	Published - Oct 2012

Keywords

Codon optimization
Host-virus interactions
Hybridization miRNA-mRNA site prediction
Inhibition of translation
Synonymous substitutions

ASJC Scopus subject areas

Structural Biology
Biochemistry
Organic Chemistry
Computational Mathematics

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10.1016/j.compbiolchem.2012.06.002

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title = "MiRNA and tropism of human parvovirus B19",

abstract = "Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2. These proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mRNAs were synthesized. Our interpretation of these results is an inhibition of translation in nonpermissive cells by human miRNAs. We bring support to our hypothesis and propose detailed experimental procedure to test it.",

keywords = "Codon optimization, Host-virus interactions, Hybridization miRNA-mRNA site prediction, Inhibition of translation, Synonymous substitutions",

author = "Olga Berillo and Vladimir Khailenko and Anatoly Ivashchenko and Lior Perlmuter-Shoshany and Alexander Bolshoy",

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AU - Berillo, Olga

AU - Khailenko, Vladimir

AU - Ivashchenko, Anatoly

AU - Perlmuter-Shoshany, Lior

AU - Bolshoy, Alexander

PY - 2012/10

Y1 - 2012/10

N2 - Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2. These proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mRNAs were synthesized. Our interpretation of these results is an inhibition of translation in nonpermissive cells by human miRNAs. We bring support to our hypothesis and propose detailed experimental procedure to test it.

AB - Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2. These proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mRNAs were synthesized. Our interpretation of these results is an inhibition of translation in nonpermissive cells by human miRNAs. We bring support to our hypothesis and propose detailed experimental procedure to test it.

KW - Codon optimization

KW - Host-virus interactions

KW - Hybridization miRNA-mRNA site prediction

KW - Inhibition of translation

KW - Synonymous substitutions

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AN - SCOPUS:84867526794

SN - 1476-9271

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SP - 1

EP - 6

JO - Computational Biology and Chemistry

JF - Computational Biology and Chemistry

ER -

MiRNA and tropism of human parvovirus B19

Abstract

Keywords

ASJC Scopus subject areas

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