MiRNA and tropism of human parvovirus B19

Olga Berillo, Vladimir Khailenko, Anatoly Ivashchenko, Lior Perlmuter-Shoshany, Alexander Bolshoy

Research output: Contribution to journalArticlepeer-review

Abstract

Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2. These proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mRNAs were synthesized. Our interpretation of these results is an inhibition of translation in nonpermissive cells by human miRNAs. We bring support to our hypothesis and propose detailed experimental procedure to test it.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalComputational Biology and Chemistry
Volume40
DOIs
StatePublished - Oct 2012

Keywords

  • Codon optimization
  • Host-virus interactions
  • Hybridization miRNA-mRNA site prediction
  • Inhibition of translation
  • Synonymous substitutions

ASJC Scopus subject areas

  • Computational Mathematics
  • Structural Biology
  • Biochemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'MiRNA and tropism of human parvovirus B19'. Together they form a unique fingerprint.

Cite this