Microsatellites: Genomic distribution, putative functions and mutational mechanisms: A review

You Chun Li; Abraham B. Korol; Tzion Fahima; Avigdor Beiles; Eviatar Nevo

doi:10.1046/j.1365-294X.2002.01643.x

Microsatellites: Genomic distribution, putative functions and mutational mechanisms: A review

You Chun Li, Abraham B. Korol, Tzion Fahima, Avigdor Beiles, Eviatar Nevo

Department of Evolutionary and Environmental Biology

Research output: Contribution to journal › Review article › peer-review

Abstract

Microsatellites, or tandem simple sequence repeats (SSR), are abundant across genomes and show high levels of polymorphism. SSR genetic and evolutionary mechanisms remain controversial. Here we attempt to summarize the available data related to SSR distribution in coding and noncoding regions of genomes and SSR functional importance. Numerous lines of evidence demonstrate that SSR genomic distribution is nonrandom. Random expansions or contractions appear to be selected against for at least part of SSR loci, presumably because of their effect on chromatin organization, regulation of gene activity, recombination, DNA replication, cell cycle, mismatch repair system, etc. This review also discusses the role of two putative mutational mechanisms, replication slippage and recombination, and their interaction in SSR variation.

Original language	English
Pages (from-to)	2453-2465
Number of pages	13
Journal	Molecular Ecology
Volume	11
Issue number	12
DOIs	https://doi.org/10.1046/j.1365-294X.2002.01643.x
State	Published - 1 Dec 2002

Keywords

Genomic distribution
Polymerase slippage
Recombination
SSR function
Size constraints

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Genetics

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10.1046/j.1365-294X.2002.01643.x

Cite this

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abstract = "Microsatellites, or tandem simple sequence repeats (SSR), are abundant across genomes and show high levels of polymorphism. SSR genetic and evolutionary mechanisms remain controversial. Here we attempt to summarize the available data related to SSR distribution in coding and noncoding regions of genomes and SSR functional importance. Numerous lines of evidence demonstrate that SSR genomic distribution is nonrandom. Random expansions or contractions appear to be selected against for at least part of SSR loci, presumably because of their effect on chromatin organization, regulation of gene activity, recombination, DNA replication, cell cycle, mismatch repair system, etc. This review also discusses the role of two putative mutational mechanisms, replication slippage and recombination, and their interaction in SSR variation.",

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AU - Li, You Chun

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AU - Beiles, Avigdor

AU - Nevo, Eviatar

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AB - Microsatellites, or tandem simple sequence repeats (SSR), are abundant across genomes and show high levels of polymorphism. SSR genetic and evolutionary mechanisms remain controversial. Here we attempt to summarize the available data related to SSR distribution in coding and noncoding regions of genomes and SSR functional importance. Numerous lines of evidence demonstrate that SSR genomic distribution is nonrandom. Random expansions or contractions appear to be selected against for at least part of SSR loci, presumably because of their effect on chromatin organization, regulation of gene activity, recombination, DNA replication, cell cycle, mismatch repair system, etc. This review also discusses the role of two putative mutational mechanisms, replication slippage and recombination, and their interaction in SSR variation.

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Microsatellites: Genomic distribution, putative functions and mutational mechanisms: A review

Abstract

Keywords

ASJC Scopus subject areas

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