Abstract
Cholesterol is essential for animal life, yet intriguingly, many animals do not synthesize cholesterol. Shamsuzzama et al. identify a pathway by which cholesterol auxotrophs convert plant and fungal sterol to cholesterol. This pathway is suggested to support widespread cholesterol auxotrophy in the animal kingdom.
| Original language | English |
|---|---|
| Pages (from-to) | 3031-3038.e7 |
| Journal | Current Biology |
| Volume | 30 |
| Issue number | 15 |
| DOIs | |
| State | Published - 3 Aug 2020 |
Bibliographical note
Publisher Copyright:© 2020 Elsevier Inc.
Keywords
- C. elegans
- Dauer larvae
- animal kingdom
- cholesterol
- cholesterol auxotrophy
- dafachronic acid
- evolution of animals
- gene loss
- plant and fungal sterols
- unicellular holozoa
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Agricultural and Biological Sciences
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