Metabolic Reconfiguration in C. elegans Suggests a Pathway for Widespread Sterol Auxotrophy in the Animal Kingdom

Shamsuzzama, Ron Lebedev, Benjamin Trabelcy, Irina Langier Goncalves, Yoram Gerchman, Amir Sapir

Research output: Contribution to journalArticlepeer-review

Abstract

Cholesterol is essential for animal life, yet intriguingly, many animals do not synthesize cholesterol. Shamsuzzama et al. identify a pathway by which cholesterol auxotrophs convert plant and fungal sterol to cholesterol. This pathway is suggested to support widespread cholesterol auxotrophy in the animal kingdom.

Original languageEnglish
Pages (from-to)3031-3038.e7
JournalCurrent Biology
Volume30
Issue number15
DOIs
StatePublished - 3 Aug 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

  • animal kingdom
  • C. elegans
  • cholesterol
  • cholesterol auxotrophy
  • dafachronic acid
  • Dauer larvae
  • evolution of animals
  • gene loss
  • plant and fungal sterols
  • unicellular holozoa

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences

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