Messenger RNA Translation Defects in Neurodegenerative Diseases.

Erik Storkebaum; Kobi Rosenblum; Nahum Sonenberg

doi:10.1056/NEJMra2215795

Messenger RNA Translation Defects in Neurodegenerative Diseases.

Erik Storkebaum, Kobi Rosenblum, Nahum Sonenberg

Department of Neurobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Translation Defects in Neurodegenerative Diseases Aberrant mRNA translation is a prominent feature in many neurodegenerative diseases. The pathological hallmark is abnormally folded protein aggregates, with a unique molecular composition.

Original language	English
Pages (from-to)	1015-1030
Number of pages	16
Journal	New England Journal of Medicine
Volume	388
Issue number	11
DOIs	https://doi.org/10.1056/NEJMra2215795
State	Published - 2023

Bibliographical note

Publisher Copyright:
© 2023 Massachusetts Medical Society.

Keywords

Amyotrophic Lateral Sclerosis
Dementia/Alzheimer Disease
Genetics
Neurology/Neurosurgery
Neuromuscular Disease
Neuroscience
Parkinson Disease

ASJC Scopus subject areas

General Medicine

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10.1056/NEJMra2215795

Cite this

@article{7e9b91ef651b4def9d35eae7556f47fe,

title = "Messenger RNA Translation Defects in Neurodegenerative Diseases.",

abstract = "Translation Defects in Neurodegenerative Diseases Aberrant mRNA translation is a prominent feature in many neurodegenerative diseases. The pathological hallmark is abnormally folded protein aggregates, with a unique molecular composition.",

keywords = "Amyotrophic Lateral Sclerosis, Dementia/Alzheimer Disease, Genetics, Neurology/Neurosurgery, Neuromuscular Disease, Neuroscience, Parkinson Disease",

author = "Erik Storkebaum and Kobi Rosenblum and Nahum Sonenberg",

note = "Publisher Copyright: {\textcopyright} 2023 Massachusetts Medical Society.",

year = "2023",

doi = "10.1056/NEJMra2215795",

language = "English",

volume = "388",

pages = "1015--1030",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

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T1 - Messenger RNA Translation Defects in Neurodegenerative Diseases.

AU - Storkebaum, Erik

AU - Rosenblum, Kobi

AU - Sonenberg, Nahum

PY - 2023

Y1 - 2023

N2 - Translation Defects in Neurodegenerative Diseases Aberrant mRNA translation is a prominent feature in many neurodegenerative diseases. The pathological hallmark is abnormally folded protein aggregates, with a unique molecular composition.

AB - Translation Defects in Neurodegenerative Diseases Aberrant mRNA translation is a prominent feature in many neurodegenerative diseases. The pathological hallmark is abnormally folded protein aggregates, with a unique molecular composition.

KW - Amyotrophic Lateral Sclerosis

KW - Dementia/Alzheimer Disease

KW - Genetics

KW - Neurology/Neurosurgery

KW - Neuromuscular Disease

KW - Neuroscience

KW - Parkinson Disease

UR - https://www.scopus.com/pages/publications/85150396443

U2 - 10.1056/NEJMra2215795

DO - 10.1056/NEJMra2215795

M3 - Article

C2 - 36920757

AN - SCOPUS:85150396443

SN - 0028-4793

VL - 388

SP - 1015

EP - 1030

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 11

ER -

Messenger RNA Translation Defects in Neurodegenerative Diseases.

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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