Mediation of cognitive function by high fat diet following stress and inflammation

S. Yehuda, S. Rabinovitz, D. I. Mostofsky

Research output: Contribution to journalArticlepeer-review


In addition to commonly advertised hazards of obesity contributed by excess dietary fat, evidence of alterations in brain chemistry and structure are well documented. This brief review examines the role of nutrients, minerals and certain lipids, primarily the essential fatty acids (FA), that are beneficial to the maintenance of good health and that may offer therapeutic options by dietary supplementation. The review also considers the damaging effects of stress, especially in pre-existing conditions of obesity and diabetes, as studied in both animals and humans. The main focus of this brief review is to examine the effects of a high fat diet on stress and the immune system with particular emphasis on brain and cognitive function.

Original languageEnglish
Pages (from-to)309-315
Number of pages7
JournalNutritional Neuroscience
Issue number5-6
StatePublished - Oct 2005
Externally publishedYes


  • Fatty acids
  • High fat diet
  • Inflammation brain chemistry
  • Omega-3
  • PUFA
  • Stress

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Neuroscience (all)
  • Nutrition and Dietetics


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