Medial vestibular nucleus in the guinea-pig: histaminergic receptors - I. An in vitro study

M. Serafin, A. Khateb, N. Vibert, P. P. Vidal, M. Mühlethaler

Research output: Contribution to journalArticlepeer-review


Antihistaminergic drugs are currently used for the symptomatic treatment of vestibular related syndromes such as vertigo and motion sickness. We therefore investigated whether histamine could modulate the firing of medial vestibular nuclei neurones (MVNn). Recently, we have demonstrated that different cell types are present among MVNn in guinea-pig brainstem slices. Bath-application of histamine at 10-4 or 10-5 M induced a small membrane depolarization accompanied by a slight decrease in membrane resistance and a reversible increase in spontaneous firing in all MVN cell types. These effects were presumably postsynaptic as they persisted in a low calcium/high magnesium solution. Using a variety of agonists and antagonists of histamine receptors (H1, H2 and H3), we conclude that these effects are mediated by H2 receptors. The companion paper is concerned with an in vivo study of the histaminergic modulation of the vestibular function (Yabe et al., in press).

Original languageEnglish
Pages (from-to)242-248
Number of pages7
JournalExperimental Brain Research
Issue number2
StatePublished - Jan 1993
Externally publishedYes


  • Arousal
  • Brainstem slices
  • Guinea pig
  • H receptors
  • Vertigo and motion sickness

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Medial vestibular nucleus in the guinea-pig: histaminergic receptors - I. An in vitro study'. Together they form a unique fingerprint.

Cite this