Medex test, a novel modality for liver disease diagnosis: A pilot study

Yoav Lurie, Dan Avi Landau, Alex Kanevsky, Sara Pel, Shira Zelber-Sagie, Ran Oren

Research output: Contribution to journalArticlepeer-review


BACKGROUND AND AIMS: Liver diseases are associated with significant morbidity and health- related expenditure. Although cost-effective treatments are available, the disease is often asymptomatic until late in its course. "Medex Test," is the noninvasive detection of liver abnormalities by the measurement of changes in electrical impedance of dermal zones. This method is based on neuroreflexology, a branch of complementary medicine. This study addressed 2 questions: can Medex Test detect liver disease, and can it measure the severity of a known liver disease. METHODS: This blinded case-control study included 2 parts. First, 113 patients with a known liver disease (hepatitis C, hepatitis B, and nonalcoholic fatty liver disease) and 85 controls with no known liver disease were evaluated by the Medex Test device. Second, necroinflammatory grading of biopsy results of 60 patients with chronic hepatitis C were compared with grade determined by Medex Test. RESULTS: Medex Test detected with high sensitivity (85%) and specificity (94.1%) the presence of liver disorders. The high rates were similar for the different disorders and were independent of age and sex. Additionally, Medex Test matched the biopsy pathologic grading of necroinflammation in 78% of patients. Positive predictive value was not affected by age and sex and was better for higher degree of necroinflammation. CONCLUSIONS: This pilot study demonstrated that Medex Test detects with high accuracy the presence of liver disorders and the necroinflammatory grade. This noninvasive, low cost test may in the future become an important tool in the diagnosis and management of liver disorders. We believe the further study of this novel method is warranted.

Original languageEnglish
Pages (from-to)700-705
Number of pages6
JournalJournal of Clinical Gastroenterology
Issue number7
StatePublished - Aug 2007
Externally publishedYes


  • Complementary medicine
  • Hepatitis B
  • Hepatitis C
  • Liver biopsy
  • Necroinflammation
  • Nonalcoholic fatty liver

ASJC Scopus subject areas

  • Gastroenterology


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