Mechanisms regulating maintenance of stem cells and the stem cell niche.

Hila Toledano; Cecilia D'Alterio; Benjamin Czech; Erel Levine; D. Leanne Jones

doi:10.1091/mbc.e11-10-0886

Mechanisms regulating maintenance of stem cells and the stem cell niche.

Hila Toledano, Cecilia D'Alterio, Benjamin Czech, Erel Levine, D. Leanne Jones

Research output: Contribution to conference › Abstract

Abstract

Adult stem cells support tissue homeostasis and repair throughout the life of an individual. Many stem cells lose the capacity for self-renewal when removed from their local microenvironment (“niche”), indicating that the niche plays a major role in controlling stem cell fate. Numerous intrinsic changes occur with age that result in altered stem cell behavior and reduced tissue maintenance and regeneration. However, changes to the local and systemic environments also occur that result in decreased stem cell activity or alterations in lineage commitment.

Original language	English
Pages	82-83
Number of pages	2
DOIs	https://doi.org/10.1091/mbc.e11-10-0886
State	Published - 2011
Externally published	Yes
Event	American Society for Cell Biology - Duration: 4 Dec 2011 → 4 Dec 2011 Conference number: 2011 https://www.molbiolcell.org/doi/suppl/10.1091/mbc.e11-10-0886

Conference

Conference	American Society for Cell Biology
Abbreviated title	ASCB Annual Meeting
Period	4/12/11 → 4/12/11
Internet address	https://www.molbiolcell.org/doi/suppl/10.1091/mbc.e11-10-0886

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10.1091/mbc.e11-10-0886

https://www.molbiolcell.org/doi/suppl/10.1091/mbc.e11-10-0886/suppl_file/regular_abstracts.pdf

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title = "Mechanisms regulating maintenance of stem cells and the stem cell niche.",

abstract = "Adult stem cells support tissue homeostasis and repair throughout the life of an individual. Many stem cells lose the capacity for self-renewal when removed from their local microenvironment (“niche”), indicating that the niche plays a major role in controlling stem cell fate. Numerous intrinsic changes occur with age that result in altered stem cell behavior and reduced tissue maintenance and regeneration. However, changes to the local and systemic environments also occur that result in decreased stem cell activity or alterations in lineage commitment.",

author = "Hila Toledano and Cecilia D'Alterio and Benjamin Czech and Erel Levine and Jones, {D. Leanne}",

year = "2011",

doi = "10.1091/mbc.e11-10-0886",

language = "English",

pages = "82--83",

note = "American Society for Cell Biology, ASCB Annual Meeting ; Conference date: 04-12-2011 Through 04-12-2011",

url = "https://www.molbiolcell.org/doi/suppl/10.1091/mbc.e11-10-0886",

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TY - CONF

T1 - Mechanisms regulating maintenance of stem cells and the stem cell niche.

AU - Toledano, Hila

AU - D'Alterio, Cecilia

AU - Czech, Benjamin

AU - Levine, Erel

AU - Jones, D. Leanne

N1 - Conference code: 2011

PY - 2011

Y1 - 2011

N2 - Adult stem cells support tissue homeostasis and repair throughout the life of an individual. Many stem cells lose the capacity for self-renewal when removed from their local microenvironment (“niche”), indicating that the niche plays a major role in controlling stem cell fate. Numerous intrinsic changes occur with age that result in altered stem cell behavior and reduced tissue maintenance and regeneration. However, changes to the local and systemic environments also occur that result in decreased stem cell activity or alterations in lineage commitment.

AB - Adult stem cells support tissue homeostasis and repair throughout the life of an individual. Many stem cells lose the capacity for self-renewal when removed from their local microenvironment (“niche”), indicating that the niche plays a major role in controlling stem cell fate. Numerous intrinsic changes occur with age that result in altered stem cell behavior and reduced tissue maintenance and regeneration. However, changes to the local and systemic environments also occur that result in decreased stem cell activity or alterations in lineage commitment.

U2 - 10.1091/mbc.e11-10-0886

DO - 10.1091/mbc.e11-10-0886

M3 - Abstract

SP - 82

EP - 83

T2 - American Society for Cell Biology

Y2 - 4 December 2011 through 4 December 2011

ER -

Mechanisms regulating maintenance of stem cells and the stem cell niche.

Abstract

Conference

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