Mechanisms regulating maintenance of stem cells and the stem cell niche.

Hila Toledano, Cecilia D'Alterio, Benjamin Czech, Erel Levine, D. Leanne Jones

Research output: Contribution to conferenceAbstract


Adult stem cells support tissue homeostasis and repair throughout the life of an individual. Many stem cells lose the capacity for self-renewal when removed from their local microenvironment (“niche”), indicating that the niche plays a major role in controlling stem cell fate. Numerous intrinsic changes occur with age that result in altered stem cell behavior and reduced tissue maintenance and regeneration. However, changes to the local and systemic environments also occur that result in decreased stem cell activity or alterations in lineage commitment.
Original languageEnglish
Number of pages2
StatePublished - 2011
Externally publishedYes
EventAmerican Society for Cell Biology -
Duration: 4 Dec 20114 Dec 2011
Conference number: 2011


ConferenceAmerican Society for Cell Biology
Abbreviated titleASCB Annual Meeting
Internet address


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