Mecanismos da intoxicação do fígado de rato causada pelo gossipol

Translated title of the contribution: Mechanisms of the intoxication of rat liver caused by gossypol

Wanderson Luís de Carvalho, Marcos Antonio Maioli, Luiz Claudio Nogueira Mendes, Daniela Bernadete Rozza, Fábio Erminio Mingatto

Research output: Contribution to journalArticlepeer-review

Abstract

The liver plays a central role in metabolism due to its interposition between the digestive tract and the general circulation of the organism. It is also the main organ involved in biotransformation of exogenous substances (xenobiotics), with ability to convert hydro-phobic compounds in water-soluble, more easily eliminated by the body. Gossypol is a toxic phenolic substance present in cotton seed (Gossypium sp.). Aiming to study the mechanisms involved in the hepatotoxicity of gossypol we evaluate its effects on the antioxidant system of rat liver performing an experiment that investigated the oxidative stress and the histopathological alterations. In this study, we used Wistar rats, divided into two groups, one that received canola oil (vehicle, Control group) and another that received gossypol at a dose of 40mg/kg body weight of the animal for 15 days (Treated group). The treatment with gossypol caused alterations in the activity of seric enzymes that indicate hepatic injury and a significant oxidative stress characterized by a decrease of reduced glutathione (GSH) levels and a consequent increase in oxidized glutathione (GSSG), including further damage to the plasma membrane and organelles showed by lipid peroxidation. The result of histopathological evaluation showed degeneration of the hepatocytes.

Translated title of the contributionMechanisms of the intoxication of rat liver caused by gossypol
Original languagePortuguese
Pages (from-to)339-344
Number of pages6
JournalPesquisa Veterinaria Brasileira
Volume33
Issue number3
DOIs
StatePublished - Mar 2013
Externally publishedYes

Keywords

  • Glutathione
  • Gossypol
  • Liver
  • Oxidative stress
  • Poisoning

ASJC Scopus subject areas

  • General Veterinary

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