Measurement of axonal fiber connectivity in consciousness evaluation

Gerry Leisman; Rafael Rodríguez Rojas; Karla Batista; Maylen Carballo; Juan M. Morales; Yasser Iturria; Calixto Machado

doi:10.1109/EEEI.2014.7005846

Measurement of axonal fiber connectivity in consciousness evaluation

Gerry Leisman, Rafael Rodríguez Rojas, Karla Batista, Maylen Carballo, Juan M. Morales, Yasser Iturria, Calixto Machado

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Background: Persistent vegetative states (PVS) and locked-in syndrome (LIS) are well-differentiated disorders of consciousness that can be reached after a localized brain injury in the brainstem. The relations of the lesion topography with the impairment in the whole-brain architecture and functional disconnections are poorly understood. Methods: Two patients (PVS and LIS) and 20 age-matched healthy volunteers were evaluated using diffusion tensor imaging (DTI). Anatomical network was modeled as a graph whose nodes are represented by 71 brain regions. Inter-region connections were quantified through Anatomical Connection Strength (ACS) and Density (ACD). Complex networks properties such as local and global efficiency and vulnerability were studied. Mass univariate testing was performed at every connection using network based statistic approach. Results: LIS patients' network showed significant differences from controls in the brainstem-thalamus-frontal cortex circuitry, while PVS patients showed a widespread disruption of anatomical connectivity in both hemispheres. Both patients showed a reorganization of network attributes, with decreased global and local efficiency, significantly more pronounced in PVS.

Original language	English
Title of host publication	2014 IEEE 28th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781479959877
DOIs	https://doi.org/10.1109/EEEI.2014.7005846
State	Published - 2014
Externally published	Yes
Event	2014 28th IEEE Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014 - Eilat, Israel Duration: 3 Dec 2014 → 5 Dec 2014

Publication series

Name	2014 IEEE 28th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014

Conference

Conference	2014 28th IEEE Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014
Country/Territory	Israel
City	Eilat
Period	3/12/14 → 5/12/14

Bibliographical note

Publisher Copyright:
© Copyright 2015 IEEE All rights reserved.

Keywords

Consciousness
Diffusion tensor imaging
Functional disconnection
Graph theory
Locked-in syndrome
Persistent vegetative state

ASJC Scopus subject areas

Electrical and Electronic Engineering

Access to Document

10.1109/EEEI.2014.7005846

Cite this

Leisman, G., Rojas, R. R., Batista, K., Carballo, M., Morales, J. M., Iturria, Y., & Machado, C. (2014). Measurement of axonal fiber connectivity in consciousness evaluation. In 2014 IEEE 28th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014 Article 7005846 (2014 IEEE 28th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EEEI.2014.7005846

Leisman, Gerry ; Rojas, Rafael Rodríguez ; Batista, Karla et al. / Measurement of axonal fiber connectivity in consciousness evaluation. 2014 IEEE 28th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014. Institute of Electrical and Electronics Engineers Inc., 2014. (2014 IEEE 28th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014).

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title = "Measurement of axonal fiber connectivity in consciousness evaluation",

abstract = "Background: Persistent vegetative states (PVS) and locked-in syndrome (LIS) are well-differentiated disorders of consciousness that can be reached after a localized brain injury in the brainstem. The relations of the lesion topography with the impairment in the whole-brain architecture and functional disconnections are poorly understood. Methods: Two patients (PVS and LIS) and 20 age-matched healthy volunteers were evaluated using diffusion tensor imaging (DTI). Anatomical network was modeled as a graph whose nodes are represented by 71 brain regions. Inter-region connections were quantified through Anatomical Connection Strength (ACS) and Density (ACD). Complex networks properties such as local and global efficiency and vulnerability were studied. Mass univariate testing was performed at every connection using network based statistic approach. Results: LIS patients' network showed significant differences from controls in the brainstem-thalamus-frontal cortex circuitry, while PVS patients showed a widespread disruption of anatomical connectivity in both hemispheres. Both patients showed a reorganization of network attributes, with decreased global and local efficiency, significantly more pronounced in PVS.",

keywords = "Consciousness, Diffusion tensor imaging, Functional disconnection, Graph theory, Locked-in syndrome, Persistent vegetative state",

author = "Gerry Leisman and Rojas, {Rafael Rodr{\'i}guez} and Karla Batista and Maylen Carballo and Morales, {Juan M.} and Yasser Iturria and Calixto Machado",

note = "Publisher Copyright: {\textcopyright} Copyright 2015 IEEE All rights reserved.; 2014 28th IEEE Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014 ; Conference date: 03-12-2014 Through 05-12-2014",

year = "2014",

doi = "10.1109/EEEI.2014.7005846",

language = "English",

series = "2014 IEEE 28th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014",

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Leisman, G, Rojas, RR, Batista, K, Carballo, M, Morales, JM, Iturria, Y & Machado, C 2014, Measurement of axonal fiber connectivity in consciousness evaluation. in 2014 IEEE 28th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014., 7005846, 2014 IEEE 28th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014, Institute of Electrical and Electronics Engineers Inc., 2014 28th IEEE Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014, Eilat, Israel, 3/12/14. https://doi.org/10.1109/EEEI.2014.7005846

Measurement of axonal fiber connectivity in consciousness evaluation. / Leisman, Gerry; Rojas, Rafael Rodríguez; Batista, Karla et al.
2014 IEEE 28th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014. Institute of Electrical and Electronics Engineers Inc., 2014. 7005846 (2014 IEEE 28th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Iturria, Yasser

AU - Machado, Calixto

PY - 2014

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AB - Background: Persistent vegetative states (PVS) and locked-in syndrome (LIS) are well-differentiated disorders of consciousness that can be reached after a localized brain injury in the brainstem. The relations of the lesion topography with the impairment in the whole-brain architecture and functional disconnections are poorly understood. Methods: Two patients (PVS and LIS) and 20 age-matched healthy volunteers were evaluated using diffusion tensor imaging (DTI). Anatomical network was modeled as a graph whose nodes are represented by 71 brain regions. Inter-region connections were quantified through Anatomical Connection Strength (ACS) and Density (ACD). Complex networks properties such as local and global efficiency and vulnerability were studied. Mass univariate testing was performed at every connection using network based statistic approach. Results: LIS patients' network showed significant differences from controls in the brainstem-thalamus-frontal cortex circuitry, while PVS patients showed a widespread disruption of anatomical connectivity in both hemispheres. Both patients showed a reorganization of network attributes, with decreased global and local efficiency, significantly more pronounced in PVS.

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PB - Institute of Electrical and Electronics Engineers Inc.

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Y2 - 3 December 2014 through 5 December 2014

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Leisman G, Rojas RR, Batista K, Carballo M, Morales JM, Iturria Y et al. Measurement of axonal fiber connectivity in consciousness evaluation. In 2014 IEEE 28th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014. Institute of Electrical and Electronics Engineers Inc. 2014. 7005846. (2014 IEEE 28th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2014). doi: 10.1109/EEEI.2014.7005846

Measurement of axonal fiber connectivity in consciousness evaluation

Abstract

Publication series

Conference

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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