Matrix metalloproteinases and skeletal muscle: A brief review

Eli Carmeli, Miri Moas, Abraham Z. Reznick, Raymond Coleman

Research output: Contribution to journalShort surveypeer-review

Abstract

Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteolytic enzymes that function mainly in the extracellular matrix, where they contribute to the development, functioning, and pathology of a wide range of tissues. This mini-review describes the MMPs and tissue inhibitors of MMPs (TIMPs) in skeletal muscle, and considers their involvement in muscle development, ischemia, myonecrosis, angiogenesis, denervation, exercise-induced injuries, disuse atrophy, muscle repair and regeneration, and inflammatory myopathies and dystrophies. Despite the very limited information currently available on MMPs and their inhibitors in skeletal muscle, it is becoming increasingly clear that they have important physiological functions in maintenance of the integrity and homeostasis of muscle fibers and of the extracellular matrix. Understanding the roles of MMPs and TIMPs may lead to the development of new drug-related treatments for various muscle disorders based on suppression or upregulation of their expression.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalMuscle and Nerve
Volume29
Issue number2
DOIs
StatePublished - Feb 2004
Externally publishedYes

Keywords

  • Extracellular matrix
  • Inflammatory myopathies
  • Matrix metalloproteinases
  • Muscle injury skeletal muscle

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)
  • Cellular and Molecular Neuroscience
  • Physiology

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