Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization after Antenatal Messenger RNA Vaccination

Amihai Rottenstreich; Olesya Vorontsov; Or Alfi; Gila Zarbiv; Esther Oiknine-Djian; Roy Zigron; Geffen Kleinstern; Michal Mandelboim; Shay Porat; Dana G. Wolf

doi:10.1093/cid/ciac395

Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization after Antenatal Messenger RNA Vaccination

Amihai Rottenstreich
, Olesya Vorontsov
, Or Alfi
, Gila Zarbiv
, Esther Oiknine-Djian
, Roy Zigron
, Geffen Kleinstern
, Michal Mandelboim
, Shay Porat
, Dana G. Wolf

School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates.

Original language	English
Pages (from-to)	2023-2026
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	75
Issue number	11
DOIs	https://doi.org/10.1093/cid/ciac395
State	Published - 1 Dec 2022

Bibliographical note

Publisher Copyright:
© 2022 The Author(s). Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COVID-19
Omicron
SARS-CoV-2
pregnancy
vaccination

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

Access to Document

10.1093/cid/ciac395

Cite this

Rottenstreich, A., Vorontsov, O., Alfi, O., Zarbiv, G., Oiknine-Djian, E., Zigron, R., Kleinstern, G., Mandelboim, M., Porat, S., & Wolf, D. G. (2022). Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization after Antenatal Messenger RNA Vaccination. Clinical Infectious Diseases, 75(11), 2023-2026. https://doi.org/10.1093/cid/ciac395

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abstract = "We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates.",

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Rottenstreich, A, Vorontsov, O, Alfi, O, Zarbiv, G, Oiknine-Djian, E, Zigron, R, Kleinstern, G, Mandelboim, M, Porat, S & Wolf, DG 2022, 'Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization after Antenatal Messenger RNA Vaccination', Clinical Infectious Diseases, vol. 75, no. 11, pp. 2023-2026. https://doi.org/10.1093/cid/ciac395

TY - JOUR

T1 - Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization after Antenatal Messenger RNA Vaccination

AU - Rottenstreich, Amihai

AU - Vorontsov, Olesya

AU - Alfi, Or

AU - Zarbiv, Gila

AU - Oiknine-Djian, Esther

AU - Zigron, Roy

AU - Kleinstern, Geffen

AU - Mandelboim, Michal

AU - Porat, Shay

AU - Wolf, Dana G.

PY - 2022/12/1

Y1 - 2022/12/1

N2 - We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates.

AB - We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates.

KW - COVID-19

KW - Omicron

KW - SARS-CoV-2

KW - pregnancy

KW - vaccination

UR - https://www.scopus.com/pages/publications/85143180545

U2 - 10.1093/cid/ciac395

DO - 10.1093/cid/ciac395

M3 - Article

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AN - SCOPUS:85143180545

SN - 1058-4838

VL - 75

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JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 11

ER -

Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization after Antenatal Messenger RNA Vaccination

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this