Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization After Antenatal Messenger RNA Vaccination

Amihai Rottenstreich; Olesya Vorontsov; Or Alfi; Gila Zarbiv; Esther Oiknine-Djian; Roy Zigron; Geffen Kleinstern; Michal Mandelboim; Shay Porat; Dana G. Wolf

doi:10.1093/cid/ciac395

Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization After Antenatal Messenger RNA Vaccination

Amihai Rottenstreich, Olesya Vorontsov, Or Alfi, Gila Zarbiv, Esther Oiknine-Djian, Roy Zigron, Geffen Kleinstern, Michal Mandelboim, Shay Porat, Dana G. Wolf

School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates.

Original language	English
Pages (from-to)	2023-2026
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	75
Issue number	11
DOIs	https://doi.org/10.1093/cid/ciac395
State	Published - 30 Nov 2022

Bibliographical note

Publisher Copyright:
© The Author(s) 2022. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Keywords

COVID-19
Omicron
pregnancy
SARS-CoV-2
vaccination

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/cid/ciac395

Cite this

Rottenstreich, A., Vorontsov, O., Alfi, O., Zarbiv, G., Oiknine-Djian, E., Zigron, R., Kleinstern, G., Mandelboim, M., Porat, S., & Wolf, D. G. (2022). Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization After Antenatal Messenger RNA Vaccination. Clinical Infectious Diseases, 75(11), 2023-2026. https://doi.org/10.1093/cid/ciac395

@article{4eeb2b799db0443c939d518656fb6a25,

title = "Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization After Antenatal Messenger RNA Vaccination",

abstract = "We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates.",

keywords = "COVID-19, Omicron, pregnancy, SARS-CoV-2, vaccination",

author = "Amihai Rottenstreich and Olesya Vorontsov and Or Alfi and Gila Zarbiv and Esther Oiknine-Djian and Roy Zigron and Geffen Kleinstern and Michal Mandelboim and Shay Porat and Wolf, {Dana G.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",

year = "2022",

month = nov,

day = "30",

doi = "10.1093/cid/ciac395",

language = "English",

volume = "75",

pages = "2023--2026",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "11",

}

Rottenstreich, A, Vorontsov, O, Alfi, O, Zarbiv, G, Oiknine-Djian, E, Zigron, R, Kleinstern, G, Mandelboim, M, Porat, S & Wolf, DG 2022, 'Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization After Antenatal Messenger RNA Vaccination', Clinical Infectious Diseases, vol. 75, no. 11, pp. 2023-2026. https://doi.org/10.1093/cid/ciac395

TY - JOUR

T1 - Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization After Antenatal Messenger RNA Vaccination

AU - Rottenstreich, Amihai

AU - Vorontsov, Olesya

AU - Alfi, Or

AU - Zarbiv, Gila

AU - Oiknine-Djian, Esther

AU - Zigron, Roy

AU - Kleinstern, Geffen

AU - Mandelboim, Michal

AU - Porat, Shay

AU - Wolf, Dana G.

N1 - Publisher Copyright: © The Author(s) 2022. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2022/11/30

Y1 - 2022/11/30

N2 - We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates.

AB - We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates.

KW - COVID-19

KW - Omicron

KW - pregnancy

KW - SARS-CoV-2

KW - vaccination

UR - http://www.scopus.com/inward/record.url?scp=85143180545&partnerID=8YFLogxK

U2 - 10.1093/cid/ciac395

DO - 10.1093/cid/ciac395

M3 - Article

C2 - 35607735

AN - SCOPUS:85143180545

SN - 1058-4838

VL - 75

SP - 2023

EP - 2026

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 11

ER -

Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization After Antenatal Messenger RNA Vaccination

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this