TY - JOUR
T1 - Love to win or hate to lose? Asymmetry of dopamine D2 receptor binding predicts sensitivity to reward versus punishment
AU - Tomer, Rachel
AU - Slagter, Heleen A.
AU - Christian, Bradley T.
AU - Fox, Andrew S.
AU - King, Carlye R.
AU - Murali, Dhanabalan
AU - Gluck, Mark A.
AU - Davidson, Richard J.
PY - 2014
Y1 - 2014
N2 - Humans show consistent differences in the extent to which their behavior reflects a bias toward appetitive approach-related behavior or avoidance of aversive stimuli [Elliot, A. J. Approach and avoidance motivation. In A. J. Elliot (Ed.), Handbook of approach and avoidance motivation (pp. 3-14). New York: Psychology Press, 2008]. We examined the hypothesis that in healthy participants this motivational bias (assessed by selfreport and by a probabilistic learning task that allows direct comparison of the relative sensitivity to reward and punishment) reflects lateralization of dopamine signaling. Using [F-18] fallypride to measure D2/D3 binding, we found that self-reported motivational bias was predicted by the asymmetry of frontal D2 binding. Similarly, striatal and frontal asymmetries in D2 dopamine receptor binding, rather than absolute binding levels, predicted individual differences in learning from reward versus punishment. These results suggest that normal variation in asymmetry of dopamine signaling may, in part, underlie human personality and cognition.
AB - Humans show consistent differences in the extent to which their behavior reflects a bias toward appetitive approach-related behavior or avoidance of aversive stimuli [Elliot, A. J. Approach and avoidance motivation. In A. J. Elliot (Ed.), Handbook of approach and avoidance motivation (pp. 3-14). New York: Psychology Press, 2008]. We examined the hypothesis that in healthy participants this motivational bias (assessed by selfreport and by a probabilistic learning task that allows direct comparison of the relative sensitivity to reward and punishment) reflects lateralization of dopamine signaling. Using [F-18] fallypride to measure D2/D3 binding, we found that self-reported motivational bias was predicted by the asymmetry of frontal D2 binding. Similarly, striatal and frontal asymmetries in D2 dopamine receptor binding, rather than absolute binding levels, predicted individual differences in learning from reward versus punishment. These results suggest that normal variation in asymmetry of dopamine signaling may, in part, underlie human personality and cognition.
UR - http://www.scopus.com/inward/record.url?scp=84897425915&partnerID=8YFLogxK
U2 - 10.1162/jocn_a_00544
DO - 10.1162/jocn_a_00544
M3 - Article
C2 - 24345165
AN - SCOPUS:84897425915
SN - 0898-929X
VL - 26
SP - 1039
EP - 1048
JO - Journal of Cognitive Neuroscience
JF - Journal of Cognitive Neuroscience
IS - 5
ER -