Long term consequences of the 1944-1945 dutch famine on the insulin-like growth factor axis

Sjoerd G. Elias; Lital Keinan-Boker; Petra H.M. Peeters; Carla H. Van Gils; Rudolf Kaaks; Diederick E. Grobbee; Paulus A.H. Van Noord

doi:10.1002/ijc.11584

Long term consequences of the 1944-1945 dutch famine on the insulin-like growth factor axis

Sjoerd G. Elias, Lital Keinan-Boker, Petra H.M. Peeters, Carla H. Van Gils, Rudolf Kaaks, Diederick E. Grobbee, Paulus A.H. Van Noord

Research output: Contribution to journal › Article › peer-review

Abstract

The insulin-like growth factor axis is highly responsive to nutritional status and may be involved as one of the underlying mechanisms through which caloric restriction could affect cancer risk. High levels of circulating insulin-like growth factor (IGF)-I, or IGF-I relative to IGF binding protein (IGFBP)-3 have been related to various human cancer types. In a group of 87 postmenopausal women, we found that childhood exposure to the 1944-1945 Dutch famine was associated with increased plasma levels of IGF-I and IGFBP-3, whereas IGFBP-1 and -2 levels were weakly decreased. These results are opposite to immediate responses seen under starvation and we hypothesize that this could indicate a permanent overshoot upon improvement of nutritional status after the famine.

Original language	English
Pages (from-to)	628-630
Number of pages	3
Journal	International Journal of Cancer
Volume	108
Issue number	4
DOIs	https://doi.org/10.1002/ijc.11584
State	Published - 4 Feb 2004
Externally published	Yes

Keywords

Caloric restriction
IGF-I
IGFBP

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ijc.11584

Cite this

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title = "Long term consequences of the 1944-1945 dutch famine on the insulin-like growth factor axis",

abstract = "The insulin-like growth factor axis is highly responsive to nutritional status and may be involved as one of the underlying mechanisms through which caloric restriction could affect cancer risk. High levels of circulating insulin-like growth factor (IGF)-I, or IGF-I relative to IGF binding protein (IGFBP)-3 have been related to various human cancer types. In a group of 87 postmenopausal women, we found that childhood exposure to the 1944-1945 Dutch famine was associated with increased plasma levels of IGF-I and IGFBP-3, whereas IGFBP-1 and -2 levels were weakly decreased. These results are opposite to immediate responses seen under starvation and we hypothesize that this could indicate a permanent overshoot upon improvement of nutritional status after the famine.",

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AU - Elias, Sjoerd G.

AU - Keinan-Boker, Lital

AU - Peeters, Petra H.M.

AU - Van Gils, Carla H.

AU - Kaaks, Rudolf

AU - Grobbee, Diederick E.

AU - Van Noord, Paulus A.H.

PY - 2004/2/4

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AB - The insulin-like growth factor axis is highly responsive to nutritional status and may be involved as one of the underlying mechanisms through which caloric restriction could affect cancer risk. High levels of circulating insulin-like growth factor (IGF)-I, or IGF-I relative to IGF binding protein (IGFBP)-3 have been related to various human cancer types. In a group of 87 postmenopausal women, we found that childhood exposure to the 1944-1945 Dutch famine was associated with increased plasma levels of IGF-I and IGFBP-3, whereas IGFBP-1 and -2 levels were weakly decreased. These results are opposite to immediate responses seen under starvation and we hypothesize that this could indicate a permanent overshoot upon improvement of nutritional status after the famine.

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KW - IGFBP

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Long term consequences of the 1944-1945 dutch famine on the insulin-like growth factor axis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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