Localized translation near the mitochondrial outer membrane: An update

Chen Lesnik, Adi Golani-Armon, Yoav Arava

Research output: Contribution to journalArticlepeer-review


Local synthesis of proteins near their activity site has been demonstrated in many biological systems, and has diverse contributions to cellular functions. Studies in recent years have revealed that hundreds of mitochondria-destined proteins are synthesized by cytosolic ribosomes near the mitochondrial outer membrane, indicating that localized translation also occurs at this cellular locus. Furthermore, in the last year central factors that are involved in this process were identified in yeast, Drosophila, and human cells. Herein we review the experimental evidence for localized translation on the cytosolic side of the mitochondrial outer membrane, in addition, we describe the factors that are involved in this process and discuss the conservation of this mechanism among various species. We also describe the relationship between localized translation and import into the mitochondria and suggest avenues of study that look beyond cotranslational import. Finally we discuss future challenges in characterizing the mechanisms for localized translation and its physiological significance.

Original languageEnglish
Pages (from-to)801-809
Number of pages9
JournalRNA Biology
Issue number8
StatePublished - 1 Jan 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC.


  • Cotranslational import
  • MRNA localization
  • Mitochondria
  • NAC
  • Om14
  • Puf3
  • Ribosome
  • Tom20
  • Translation

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Localized translation near the mitochondrial outer membrane: An update'. Together they form a unique fingerprint.

Cite this