Local activation of CA1 pyramidal cells induces theta-phase precession

Hadas E. Sloin, Lidor Spivak, Amir Levi, Roni Gattegno, Shirly Someck, Eran Stark

Research output: Contribution to journalArticlepeer-review


Hippocampal theta-phase precession is involved in spatiotemporal coding and in generating multineural spike sequences, but how precession originates remains unresolved. To determine whether precession can be generated directly in hippocampal area CA1 and disambiguate multiple competing mechanisms, we used closed-loop optogenetics to impose artificial place fields in pyramidal cells of mice running on a linear track. More than one-third of the CA1 artificial fields exhibited synthetic precession that persisted for a full theta cycle. By contrast, artificial fields in the parietal cortex did not exhibit synthetic precession. These findings are incompatible with precession models based on inheritance, dual-input, spreading activation, inhibition-excitation summation, or somato-dendritic competition. Thus, a precession generator resides locally within CA1.

Original languageEnglish
Pages (from-to)551-558
Number of pages8
Issue number6682
StatePublished - 2 Feb 2024

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