Abstract
Light-at-night (LAN) is a worldwide problem co-distributed with breast cancer prevalence. We hypothesized that exposure to LAN is coincided with a decreased melatonin (MLT) secretion level, followed by epigenetic modifications and resulted in higher breast cancer tumors growth-rate. Accordingly, we studied the effect of LAN exposure and exogenous MLT on breast cancer tumors growth-rate. 4T1 cells were inoculated into BALB/c short day-acclimated mice, resulting in tumors growth. Growth rates were followed under various light exposures and global DNA methylations were measured. Results demonstrated the positive effect of LAN on tumors growth-rate, reversed by MLT through global DNA methylation.
| Original language | English |
|---|---|
| Pages (from-to) | 144-150 |
| Number of pages | 7 |
| Journal | Chronobiology International |
| Volume | 31 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2014 |
Bibliographical note
Funding Information:The authors declare no conflict of interests. Authors are thankful to the Research Authority, the University of Haifa, for their partial financial support.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Breast cancer
- Epigenetic modifications
- Global methylation state
- Light at night
- Melatonin
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
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