Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation

Hagit Schwimmer; Avishag Metzer; Yonit Pilosof; Moshe Szyf; Ziv M. Machnes; Fuad Fares; Orna Harel; Abraham Haim

doi:10.3109/07420528.2013.842925

Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation

Hagit Schwimmer, Avishag Metzer, Yonit Pilosof, Moshe Szyf, Ziv M. Machnes, Fuad Fares, Orna Harel, Abraham Haim

Research output: Contribution to journal › Article › peer-review

Abstract

Light-at-night (LAN) is a worldwide problem co-distributed with breast cancer prevalence. We hypothesized that exposure to LAN is coincided with a decreased melatonin (MLT) secretion level, followed by epigenetic modifications and resulted in higher breast cancer tumors growth-rate. Accordingly, we studied the effect of LAN exposure and exogenous MLT on breast cancer tumors growth-rate. 4T1 cells were inoculated into BALB/c short day-acclimated mice, resulting in tumors growth. Growth rates were followed under various light exposures and global DNA methylations were measured. Results demonstrated the positive effect of LAN on tumors growth-rate, reversed by MLT through global DNA methylation.

Original language	English
Pages (from-to)	144-150
Number of pages	7
Journal	Chronobiology International
Volume	31
Issue number	1
DOIs	https://doi.org/10.3109/07420528.2013.842925
State	Published - Feb 2014

Bibliographical note

Funding Information:
The authors declare no conflict of interests. Authors are thankful to the Research Authority, the University of Haifa, for their partial financial support.

Keywords

Breast cancer
Epigenetic modifications
Global methylation state
Light at night
Melatonin

ASJC Scopus subject areas

Physiology
Physiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3109/07420528.2013.842925

Cite this

@article{fde70521b68841d9b233ad38e810616b,

title = "Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation",

abstract = "Light-at-night (LAN) is a worldwide problem co-distributed with breast cancer prevalence. We hypothesized that exposure to LAN is coincided with a decreased melatonin (MLT) secretion level, followed by epigenetic modifications and resulted in higher breast cancer tumors growth-rate. Accordingly, we studied the effect of LAN exposure and exogenous MLT on breast cancer tumors growth-rate. 4T1 cells were inoculated into BALB/c short day-acclimated mice, resulting in tumors growth. Growth rates were followed under various light exposures and global DNA methylations were measured. Results demonstrated the positive effect of LAN on tumors growth-rate, reversed by MLT through global DNA methylation.",

keywords = "Breast cancer, Epigenetic modifications, Global methylation state, Light at night, Melatonin",

author = "Hagit Schwimmer and Avishag Metzer and Yonit Pilosof and Moshe Szyf and Machnes, {Ziv M.} and Fuad Fares and Orna Harel and Abraham Haim",

note = "Funding Information: The authors declare no conflict of interests. Authors are thankful to the Research Authority, the University of Haifa, for their partial financial support.",

year = "2014",

month = feb,

doi = "10.3109/07420528.2013.842925",

language = "English",

volume = "31",

pages = "144--150",

journal = "Chronobiology International",

issn = "0742-0528",

publisher = "Marcel Dekker Inc.",

number = "1",

}

TY - JOUR

T1 - Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation

AU - Schwimmer, Hagit

AU - Metzer, Avishag

AU - Pilosof, Yonit

AU - Szyf, Moshe

AU - Machnes, Ziv M.

AU - Fares, Fuad

AU - Harel, Orna

AU - Haim, Abraham

N1 - Funding Information: The authors declare no conflict of interests. Authors are thankful to the Research Authority, the University of Haifa, for their partial financial support.

PY - 2014/2

Y1 - 2014/2

N2 - Light-at-night (LAN) is a worldwide problem co-distributed with breast cancer prevalence. We hypothesized that exposure to LAN is coincided with a decreased melatonin (MLT) secretion level, followed by epigenetic modifications and resulted in higher breast cancer tumors growth-rate. Accordingly, we studied the effect of LAN exposure and exogenous MLT on breast cancer tumors growth-rate. 4T1 cells were inoculated into BALB/c short day-acclimated mice, resulting in tumors growth. Growth rates were followed under various light exposures and global DNA methylations were measured. Results demonstrated the positive effect of LAN on tumors growth-rate, reversed by MLT through global DNA methylation.

AB - Light-at-night (LAN) is a worldwide problem co-distributed with breast cancer prevalence. We hypothesized that exposure to LAN is coincided with a decreased melatonin (MLT) secretion level, followed by epigenetic modifications and resulted in higher breast cancer tumors growth-rate. Accordingly, we studied the effect of LAN exposure and exogenous MLT on breast cancer tumors growth-rate. 4T1 cells were inoculated into BALB/c short day-acclimated mice, resulting in tumors growth. Growth rates were followed under various light exposures and global DNA methylations were measured. Results demonstrated the positive effect of LAN on tumors growth-rate, reversed by MLT through global DNA methylation.

KW - Breast cancer

KW - Epigenetic modifications

KW - Global methylation state

KW - Light at night

KW - Melatonin

UR - http://www.scopus.com/inward/record.url?scp=84892420352&partnerID=8YFLogxK

U2 - 10.3109/07420528.2013.842925

DO - 10.3109/07420528.2013.842925

M3 - Article

C2 - 24131150

AN - SCOPUS:84892420352

SN - 0742-0528

VL - 31

SP - 144

EP - 150

JO - Chronobiology International

JF - Chronobiology International

IS - 1

ER -

Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this