Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation

Hagit Schwimmer, Avishag Metzer, Yonit Pilosof, Moshe Szyf, Ziv M. Machnes, Fuad Fares, Orna Harel, Abraham Haim

Research output: Contribution to journalArticlepeer-review

Abstract

Light-at-night (LAN) is a worldwide problem co-distributed with breast cancer prevalence. We hypothesized that exposure to LAN is coincided with a decreased melatonin (MLT) secretion level, followed by epigenetic modifications and resulted in higher breast cancer tumors growth-rate. Accordingly, we studied the effect of LAN exposure and exogenous MLT on breast cancer tumors growth-rate. 4T1 cells were inoculated into BALB/c short day-acclimated mice, resulting in tumors growth. Growth rates were followed under various light exposures and global DNA methylations were measured. Results demonstrated the positive effect of LAN on tumors growth-rate, reversed by MLT through global DNA methylation.

Original languageEnglish
Pages (from-to)144-150
Number of pages7
JournalChronobiology International
Volume31
Issue number1
DOIs
StatePublished - Feb 2014

Bibliographical note

Funding Information:
The authors declare no conflict of interests. Authors are thankful to the Research Authority, the University of Haifa, for their partial financial support.

Keywords

  • Breast cancer
  • Epigenetic modifications
  • Global methylation state
  • Light at night
  • Melatonin

ASJC Scopus subject areas

  • Physiology (medical)
  • Physiology

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