Left hemisphere hyperactivity in schizophrenia: Abnormality inherent to psychosis or neuroleptic side-effects?

Rachel Tomer; Matti Mintz; Michael S. Myslobodsky

doi:10.1007/BF00431942

Left hemisphere hyperactivity in schizophrenia: Abnormality inherent to psychosis or neuroleptic side-effects?

Rachel Tomer, Matti Mintz, Michael S. Myslobodsky

Research output: Contribution to journal › Article › peer-review

Abstract

Studies measuring reflective lateral eye movements (LEM) in schizophrenic patients revealed predominance of rightward LEMs, which was interpreted as suggesting left hemisphere overactivation in schizophrenia. In the present study LEM behaviour of medicated schizophrenics was compared to that of non-medicated patients. Rightward LEMs were predominant in a group of patients treated with phenothiazines with piperazine side chains, whereas among schizophrenics treated with non-piperazine drugs leftward LEMs were more predominant. This finding suggests that previous reports on LEM directionality in schizophrenia may have been confounded by neuroleptic medication. The possible effect of piperazine derivatives on hemispheric balance is discussed.

Original language	English
Pages (from-to)	168-170
Number of pages	3
Journal	Psychopharmacology
Volume	77
Issue number	2
DOIs	https://doi.org/10.1007/BF00431942
State	Published - Jun 1982
Externally published	Yes

Keywords

Hemispheric asymmetry
Lateral eye movements
Neuroleptics
Piperazine
Schizophrenia

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00431942

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title = "Left hemisphere hyperactivity in schizophrenia: Abnormality inherent to psychosis or neuroleptic side-effects?",

abstract = "Studies measuring reflective lateral eye movements (LEM) in schizophrenic patients revealed predominance of rightward LEMs, which was interpreted as suggesting left hemisphere overactivation in schizophrenia. In the present study LEM behaviour of medicated schizophrenics was compared to that of non-medicated patients. Rightward LEMs were predominant in a group of patients treated with phenothiazines with piperazine side chains, whereas among schizophrenics treated with non-piperazine drugs leftward LEMs were more predominant. This finding suggests that previous reports on LEM directionality in schizophrenia may have been confounded by neuroleptic medication. The possible effect of piperazine derivatives on hemispheric balance is discussed.",

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year = "1982",

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PY - 1982/6

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AB - Studies measuring reflective lateral eye movements (LEM) in schizophrenic patients revealed predominance of rightward LEMs, which was interpreted as suggesting left hemisphere overactivation in schizophrenia. In the present study LEM behaviour of medicated schizophrenics was compared to that of non-medicated patients. Rightward LEMs were predominant in a group of patients treated with phenothiazines with piperazine side chains, whereas among schizophrenics treated with non-piperazine drugs leftward LEMs were more predominant. This finding suggests that previous reports on LEM directionality in schizophrenia may have been confounded by neuroleptic medication. The possible effect of piperazine derivatives on hemispheric balance is discussed.

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Left hemisphere hyperactivity in schizophrenia: Abnormality inherent to psychosis or neuroleptic side-effects?

Abstract

Keywords

ASJC Scopus subject areas

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